Anticancer effect of docetaxel/hydroxypropyl-beta-cyclodextrin complex without histamine release
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Tae Kon | - |
dc.contributor.author | Yoo, Hye Hyun | - |
dc.date.accessioned | 2021-06-22T18:42:08Z | - |
dc.date.available | 2021-06-22T18:42:08Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 1388-3127 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/16474 | - |
dc.description.abstract | In this study, the anticancer effect and improved safety for hypesensitivity reactions of docetaxel/hydroxypropyl-beta-cyclodextrin complex (DCX-CD) were investigated. The preparation of DCX-CD was confirmed by using differential scanning calorimetry, X-ray powder diffraction analysis, and scanning electron microscope. The anticancer activity was tested in human lung cancer A549 cell-transplanted mice and the hypersensitivity was tested in Beagle dogs after intravenous administration of DCX-CD, Taxotere, and their respective vehicles. In the hypersensitivity test, plasma histamine levels were determined using an ELISA method. Our results showed that DCX-CD was pharmacologically equivalent to Taxotere. Furthermore, DCX-CD did not cause the release of histamines or any significant symptoms associated with hypersensitivity. These results suggested that DCX-CD could be a promising alternative to Taxotere for cancer chemotherapy with reduced side effects. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | Anticancer effect of docetaxel/hydroxypropyl-beta-cyclodextrin complex without histamine release | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Hye Hyun | - |
dc.identifier.doi | 10.1007/s10847-015-0571-2 | - |
dc.identifier.scopusid | 2-s2.0-84958777098 | - |
dc.identifier.wosid | 000364225300015 | - |
dc.identifier.bibliographicCitation | Journal of Inclusion Phenomena and Macrocyclic Chemistry , v.83, no.3-4, pp.355 - 361 | - |
dc.relation.isPartOf | Journal of Inclusion Phenomena and Macrocyclic Chemistry | - |
dc.citation.title | Journal of Inclusion Phenomena and Macrocyclic Chemistry | - |
dc.citation.volume | 83 | - |
dc.citation.number | 3-4 | - |
dc.citation.startPage | 355 | - |
dc.citation.endPage | 361 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | DOCETAXEL FORMULATION | - |
dc.subject.keywordPlus | TAXOTERE | - |
dc.subject.keywordPlus | SID530 | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordAuthor | Docetaxel | - |
dc.subject.keywordAuthor | HP-beta-CD | - |
dc.subject.keywordAuthor | Anticancer activity | - |
dc.subject.keywordAuthor | Hypersensitivity | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs10847-015-0571-2 | - |
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