Evaluation of phlorofucofuroeckol-A isolated from Ecklonia cava (Phaeophyta) on anti-lipid peroxidation in vitro and in vivo
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji-Hyeok | - |
dc.contributor.author | Ko, Ju-Young | - |
dc.contributor.author | Oh, Jae-Young | - |
dc.contributor.author | Kim, Eun-A | - |
dc.contributor.author | Kim, Chul-Young | - |
dc.contributor.author | Jeon, You-Jin | - |
dc.date.accessioned | 2021-06-22T18:42:37Z | - |
dc.date.available | 2021-06-22T18:42:37Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 1226-2617 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/16495 | - |
dc.description.abstract | Lipid peroxidation means the oxidative degradation of lipids. The process from the cell membrane lipids in an organism is generated by free radicals, and result in cell damage. Phlorotannins, well-known marine brown algal polyphenols, have been utilized in functional food supplements as well as in medicine supplements to serve a variety of purposes. In this study, we assessed the potential anti-lipid peroxidation activity of phlorofucofuroeckol-A (PFF-A), one of the phlorotannins, isolated from Ecklonia cava by centrifugal partition chromatography in 2,2-azobis (2-amidinopropane) dihydrochloride (AAPH) -stimulated Vero cells and zebrafish system. PFF-A showed the strongest scavenging activity against alkyl radicals of all other reactive oxygen species (ROS) and exhibited a strong protective effect against ROS and a significantly strong inhibited of malondialdehyde in AAPH-stimulated Vero cells. The apoptotic bodies and pro-apoptotic proteins Bax and caspase-3, which were induced by AAPH, were strongly inhibited by PFF-A in a dose-dependent manner and expression of Bcl-xL, an anti-apoptotic protein, was induced. In the AAPH-stimulated zebrafish model, additionally PFF-A significantly inhibited ROS and cell death, as well as exhibited a strong protective effect against lipid permddation. Therefore, these results suggest that PFF-A has excellent protective effects against ROS and lipid peroxidation induced by AAPH in both an in vitro Vero cell model and an in vivo zebrafish model. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC PHYCOLOGY | - |
dc.title | Evaluation of phlorofucofuroeckol-A isolated from Ecklonia cava (Phaeophyta) on anti-lipid peroxidation in vitro and in vivo | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chul-Young | - |
dc.identifier.doi | 10.4490/algae.2015.30.4.313 | - |
dc.identifier.scopusid | 2-s2.0-84954440396 | - |
dc.identifier.wosid | 000367636900007 | - |
dc.identifier.bibliographicCitation | ALGAE, v.30, no.4, pp.313 - 323 | - |
dc.relation.isPartOf | ALGAE | - |
dc.citation.title | ALGAE | - |
dc.citation.volume | 30 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 313 | - |
dc.citation.endPage | 323 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002056187 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Marine & Freshwater Biology | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Marine & Freshwater Biology | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | BROWN-ALGAE | - |
dc.subject.keywordPlus | PHLOROTANNINS | - |
dc.subject.keywordPlus | ANTIOXIDANTS | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ZEBRAFISH | - |
dc.subject.keywordPlus | COMPOUND | - |
dc.subject.keywordPlus | RADICALS | - |
dc.subject.keywordAuthor | AAPH | - |
dc.subject.keywordAuthor | Ecklonia cava | - |
dc.subject.keywordAuthor | lipid peroxidation | - |
dc.subject.keywordAuthor | phlorofucofuroeckol-A | - |
dc.subject.keywordAuthor | Vero cell model | - |
dc.subject.keywordAuthor | zebrafish model | - |
dc.identifier.url | https://www.e-algae.org/journal/view.php?doi=10.4490/algae.2015.30.4.313 | - |
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