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Formal Synthesis of Fesoterodine by Acid-Facilitated Aromatic Alkylation
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lee, Youngeun | - |
| dc.contributor.author | Shabbir, Saira | - |
| dc.contributor.author | Jeong, Yuri | - |
| dc.contributor.author | Ban, Jaeyoung | - |
| dc.contributor.author | Rhee, Hakjune | - |
| dc.date.accessioned | 2021-06-22T18:42:41Z | - |
| dc.date.available | 2021-06-22T18:42:41Z | - |
| dc.date.issued | 2015-12 | - |
| dc.identifier.issn | 0253-2964 | - |
| dc.identifier.issn | 1229-5949 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/16497 | - |
| dc.description.abstract | The competitive muscarinic receptor antagonist fesoterodine is a congener of tolterodine and has better efficiency compared to tolterodine. In this study, we present an efficient synthesis of the fesoterodine intermediate 3-(3-diisopropylamino-1-phenylpropyl)-4-hydroxybenzaldehyde from ethyl benzoylacetate by Friedel-Crafts alkylation in the presence of an acid as a key reaction step. The synthesis is carried out by the reduction of the ketoester to a 1,3-diol, diisopropylamine substitution, and Friedel-Crafts alkylation, followed by reduction and chiral resolution. | - |
| dc.format.extent | 5 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | 대한화학회 | - |
| dc.title | Formal Synthesis of Fesoterodine by Acid-Facilitated Aromatic Alkylation | - |
| dc.type | Article | - |
| dc.publisher.location | 대한민국 | - |
| dc.identifier.doi | 10.1002/bkcs.10592 | - |
| dc.identifier.scopusid | 2-s2.0-84955692567 | - |
| dc.identifier.wosid | 000368125200020 | - |
| dc.identifier.bibliographicCitation | Bulletin of the Korean Chemical Society, v.36, no.12, pp 2885 - 2889 | - |
| dc.citation.title | Bulletin of the Korean Chemical Society | - |
| dc.citation.volume | 36 | - |
| dc.citation.number | 12 | - |
| dc.citation.startPage | 2885 | - |
| dc.citation.endPage | 2889 | - |
| dc.type.docType | Article | - |
| dc.identifier.kciid | ART002055925 | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | sci | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.description.journalRegisteredClass | kci | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
| dc.subject.keywordPlus | OVERACTIVE BLADDER | - |
| dc.subject.keywordPlus | TOLTERODINE | - |
| dc.subject.keywordAuthor | Electrophilic aromatic substitution | - |
| dc.subject.keywordAuthor | Chiral resolution | - |
| dc.subject.keywordAuthor | Reduction | - |
| dc.subject.keywordAuthor | Acylation | - |
| dc.subject.keywordAuthor | Sulfonation | - |
| dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/bkcs.10592 | - |
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Related Researcher
- Rhee, Hak june
- ERICA 공학대학 (ERICA 에너지바이오학과)