A novel nanoprobe for the sensitive detection of Francisella tularensis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ji-eun | - |
dc.contributor.author | Seo, Youngmin | - |
dc.contributor.author | Jeong, Yoon | - |
dc.contributor.author | Hwang, Mintai P. | - |
dc.contributor.author | Hwang, Jangsun | - |
dc.contributor.author | Choo, Jaeburn | - |
dc.contributor.author | Hong, Jong Wook | - |
dc.contributor.author | Jeon, Jun Ho | - |
dc.contributor.author | Rhie, Gi-eun | - |
dc.contributor.author | Choi, Jonghoon | - |
dc.date.accessioned | 2021-06-22T18:43:05Z | - |
dc.date.available | 2021-06-22T18:43:05Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 0304-3894 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/16518 | - |
dc.description.abstract | Francisella tularensis is a human zoonotic pathogen and the causative agent of tularemia, a severe infectious disease. Given the extreme infectivity of F. tularensis and its potential to be used as a biological warfare agent, a fast and sensitive detection method is highly desirable. Herein, we construct a novel detection platform composed of two units: (I) Magnetic beads conjugated with multiple capturing antibodies against F. tularensis for its simple and rapid separation and (2) Genetically-engineered apoferritin protein constructs conjugated with multiple quantum dots and a detection antibody against F. tularensis for the amplification of signal. We demonstrate a 10-fold increase in the sensitivity relative to traditional lateral flow devices that utilize enzyme-based detection methods. We ultimately envision the use of our novel nanoprobe detection platform in future applications that require the highly-sensitive on-site detection of high-risk pathogens. (C) 2015 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | A novel nanoprobe for the sensitive detection of Francisella tularensis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Jong Wook | - |
dc.identifier.doi | 10.1016/j.jhazmat.2015.05.041 | - |
dc.identifier.scopusid | 2-s2.0-84930639081 | - |
dc.identifier.wosid | 000360595800021 | - |
dc.identifier.bibliographicCitation | JOURNAL OF HAZARDOUS MATERIALS, v.298, pp.188 - 194 | - |
dc.relation.isPartOf | JOURNAL OF HAZARDOUS MATERIALS | - |
dc.citation.title | JOURNAL OF HAZARDOUS MATERIALS | - |
dc.citation.volume | 298 | - |
dc.citation.startPage | 188 | - |
dc.citation.endPage | 194 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalWebOfScienceCategory | Engineering, Environmental | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.subject.keywordPlus | NATURAL FOCI | - |
dc.subject.keywordPlus | TULAREMIA | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | ASSAY | - |
dc.subject.keywordPlus | PCR | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | PLATFORM | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | AGENTS | - |
dc.subject.keywordAuthor | Nanoprobes | - |
dc.subject.keywordAuthor | Francisella tularensis | - |
dc.subject.keywordAuthor | Apoferritin | - |
dc.subject.keywordAuthor | Immunoassay | - |
dc.subject.keywordAuthor | Biosensing | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0304389415004379?via%3Dihub | - |
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