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Synthesis of stereochemically diverse cyclic analogs of tubulysins
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Park, Yunjeong | - |
| dc.contributor.author | Bae, Song Yi | - |
| dc.contributor.author | Hah, Jung-Mi | - |
| dc.contributor.author | Lee, Sang Kook | - |
| dc.contributor.author | Ryu, Jae-Sang | - |
| dc.date.accessioned | 2021-06-22T18:43:31Z | - |
| dc.date.available | 2021-06-22T18:43:31Z | - |
| dc.date.issued | 2015-11 | - |
| dc.identifier.issn | 0968-0896 | - |
| dc.identifier.issn | 1464-3391 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/16538 | - |
| dc.description.abstract | The synthesis of tubulysin analogs containing stereochemically diverse cyclic Tuv moieties is described. A tetrahydropyranyl moiety was incorporated into the Tuv unit by enantioselective hetero Diels-Alder reactions of Danishefsky's diene and thiazole aldehyde. Four different stereoisomers of cyclic Tuv units were used as surrogates for the Tuv moiety. The synthesized stereochemically diverse simplified cyclic analogs were evaluated for the inhibition of tubulin polymerization. (C) 2015 Elsevier Ltd. All rights reserved. | - |
| dc.format.extent | 17 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
| dc.title | Synthesis of stereochemically diverse cyclic analogs of tubulysins | - |
| dc.type | Article | - |
| dc.publisher.location | 영국 | - |
| dc.identifier.doi | 10.1016/j.bmc.2015.10.003 | - |
| dc.identifier.scopusid | 2-s2.0-84946110449 | - |
| dc.identifier.wosid | 000364437400006 | - |
| dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY, v.23, no.21, pp 6827 - 6843 | - |
| dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY | - |
| dc.citation.volume | 23 | - |
| dc.citation.number | 21 | - |
| dc.citation.startPage | 6827 | - |
| dc.citation.endPage | 6843 | - |
| dc.type.docType | Article | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | sci | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.subject.keywordPlus | SIMPLIFIED PRETUBULYSIN DERIVATIVES | - |
| dc.subject.keywordPlus | N-METHYLAMINO ACIDS | - |
| dc.subject.keywordPlus | BIOLOGICAL EVALUATION | - |
| dc.subject.keywordPlus | BOND FORMATION | - |
| dc.subject.keywordPlus | RACEMIZATION | - |
| dc.subject.keywordPlus | CYTOTOXICITY | - |
| dc.subject.keywordPlus | MYXOBACTERIA | - |
| dc.subject.keywordPlus | DANISHEFSKYS | - |
| dc.subject.keywordPlus | ANTICANCER | - |
| dc.subject.keywordPlus | INHIBITORS | - |
| dc.subject.keywordAuthor | Tubulysin | - |
| dc.subject.keywordAuthor | Antitumor agents | - |
| dc.subject.keywordAuthor | Peptides | - |
| dc.subject.keywordAuthor | Asymmetric catalysis | - |
| dc.subject.keywordAuthor | Hetero Diels-Alder reaction | - |
| dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S096808961530081X?via%3Dihub | - |
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Related Researcher
- Hah, Jung Mi
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)