Nectandrin B, a lignan isolated from nutmeg, inhibits liver X receptor-alpha-induced hepatic lipogenesis through AMP-activated protein kinase activation
DC Field | Value | Language |
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dc.contributor.author | Choi, Du Gon | - |
dc.contributor.author | Kim, Eun Kyung | - |
dc.contributor.author | Yang, Jin Won | - |
dc.contributor.author | Song, Jae Sook | - |
dc.contributor.author | Kim, Young-Mi | - |
dc.date.accessioned | 2021-06-22T18:44:17Z | - |
dc.date.available | 2021-06-22T18:44:17Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 0031-7144 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/16578 | - |
dc.description.abstract | Nonalcoholic fatty liver disease is recognized as the most commonly occurring chronic liver disease. Liver X receptor alpha (LXR alpha) and sterol regulatory element-binding protein (SREBP)-1c play a central role in de novo fatty acid synthesis. This study investigated pharmacological effects of nectandrin B, a lignan isolated from nutmeg extract, on hepatic lipogenesis stimulated by LXR alpha -SREBP-1c-mediated pathway and the possible molecular basis. The reporter gene assay revealed that nectandrin B completely represses LXR alpha activity enhanced by a synthetic LXR alpha ligand (T0901317) in HepG2 cells. The inhibitory effect was further supported by the suppression of mRNA expression of LXR alpha target genes, SREBP-1c and LXR alpha itself. Nectandrin B also inhibited the increase in SREBP-1c expression promoted by insulin plus high glucose, major contributors to hepatic lipid accumulation. LXR alpha -SREBP-1c-mediated induction of acetylCoA carboxylase 1 and fatty acid synthase, major genes for de novo lipogenesis, was suppressed by nectandrin B. Moreover, Oil Red O staining showed that nectandrin B notably attenuates LXR alpha-induced lipid accumulation. AMP-activated protein kinase (AMPK) inhibits the activities of LXR alpha and SREBP-1c. Nectandrin B strongly activated AMPK signaling in HepG2 cells. Taken together, the suppressive effects of nectandrin B on lipogenic gene expression and lipid accumulation in hepatocytes may be due to its inhibitory effect on the LXR alpha-SREBP-1c pathway presumably via AMPK activation. These results suggest the potential of nectandrin B as a therapeutic candidate for fatty liver disease. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH | - |
dc.title | Nectandrin B, a lignan isolated from nutmeg, inhibits liver X receptor-alpha-induced hepatic lipogenesis through AMP-activated protein kinase activation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Young-Mi | - |
dc.identifier.doi | 10.1691/ph.2015.5661 | - |
dc.identifier.scopusid | 2-s2.0-84961815146 | - |
dc.identifier.wosid | 000369614300007 | - |
dc.identifier.bibliographicCitation | PHARMAZIE, v.70, no.11, pp.733 - 739 | - |
dc.relation.isPartOf | PHARMAZIE | - |
dc.citation.title | PHARMAZIE | - |
dc.citation.volume | 70 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 733 | - |
dc.citation.endPage | 739 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | MYRISTICA-FRAGRANS NUTMEG | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS ROLE | - |
dc.subject.keywordPlus | FATTY LIVER | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | STEATOSIS | - |
dc.subject.keywordPlus | SREBP-1C | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | LXR | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordAuthor | ELEMENT-BINDING PROTEIN-1C | - |
dc.subject.keywordAuthor | MYRISTICA-FRAGRANS NUTMEG | - |
dc.subject.keywordAuthor | ENDOTHELIAL-CELLS ROLE | - |
dc.subject.keywordAuthor | FATTY LIVER | - |
dc.subject.keywordAuthor | METABOLIC SYNDROME | - |
dc.subject.keywordAuthor | MOUSE-LIVER | - |
dc.subject.keywordAuthor | EXPRESSION | - |
dc.subject.keywordAuthor | PATHWAY | - |
dc.subject.keywordAuthor | STEATOSIS | - |
dc.subject.keywordAuthor | SREBP-1C | - |
dc.identifier.url | https://www.ingentaconnect.com/contentone/govi/pharmaz/2015/00000070/00000011/art00007 | - |
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