Resident c-kit(+) cells in the heart are not cardiac stem cells
DC Field | Value | Language |
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dc.contributor.author | Sultana, Nishat | - |
dc.contributor.author | Zhang, Lu | - |
dc.contributor.author | Yan, Jianyun | - |
dc.contributor.author | Chen, Jiqiu | - |
dc.contributor.author | Cai, Weibin | - |
dc.contributor.author | Razzaque, Shegufta | - |
dc.contributor.author | Jeong, Dongtak | - |
dc.contributor.author | Sheng, Wei | - |
dc.contributor.author | Bu, Lei | - |
dc.contributor.author | Xu, Mingjiang | - |
dc.contributor.author | Huang, Guo-Ying | - |
dc.contributor.author | Hajjar, Roger J. | - |
dc.contributor.author | Zhou, Bin | - |
dc.contributor.author | Moon, Anne | - |
dc.contributor.author | Cai, Chen-Leng | - |
dc.date.accessioned | 2021-06-22T19:03:12Z | - |
dc.date.available | 2021-06-22T19:03:12Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2015-10 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/17006 | - |
dc.description.abstract | Identifying a bona fide population of cardiac stem cells (CSCs) is a critical step for developing cell-based therapies for heart failure patients. Previously, cardiac c-kit(+) cells were reported to be CSCs with a potential to become myocardial, endothelial and smooth muscle cells in vitro and after cardiac injury. Here we provide further insights into the nature of cardiac c-kit(+) cells. By targeting the c-kit locus with multiple reporter genes in mice, we find that c-kit expression rarely co-localizes with the expression of the cardiac progenitor and myogenic marker Nkx2.5, or that of the myocardial marker, cardiac troponin T (cTnT). Instead, c-kit predominantly labels a cardiac endothelial cell population in developing and adult hearts. After acute cardiac injury, c-kit(+) cells retain their endothelial identity and do not become myogenic progenitors or cardiomyocytes. Thus, our work strongly suggests that c-kit(+) cells in the murine heart are endothelial cells and not CSCs. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Resident c-kit(+) cells in the heart are not cardiac stem cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeong, Dongtak | - |
dc.identifier.doi | 10.1038/ncomms9701 | - |
dc.identifier.wosid | 000364937900001 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.6, pp.1 - 10 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 6 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | CRE KNOCK-INS | - |
dc.subject.keywordPlus | C-KIT LOCUS | - |
dc.subject.keywordPlus | VENTRICULAR MYOCYTES | - |
dc.subject.keywordPlus | ADULT-MOUSE | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | MULTIPOTENT | - |
dc.subject.keywordPlus | PITFALLS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ABSENCE | - |
dc.identifier.url | https://www.nature.com/articles/ncomms9701 | - |
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