Orphan Nuclear Receptor ERR alpha Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation
DC Field | Value | Language |
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dc.contributor.author | Yuk, Jae-Min | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.contributor.author | Kim, Soo Yeon | - |
dc.contributor.author | Lee, Hye-Mi | - |
dc.contributor.author | Han, Jeongsu | - |
dc.contributor.author | Dufour, Catherine Rosa | - |
dc.contributor.author | Kim, Jin Kyung | - |
dc.contributor.author | Jin, Hyo Sun | - |
dc.contributor.author | Yang, Chul-Su | - |
dc.contributor.author | Park, Ki-Sun | - |
dc.contributor.author | Lee, Chul-Ho | - |
dc.contributor.author | Kim, Jin-Man | - |
dc.contributor.author | Kweon, Gi Ryang | - |
dc.contributor.author | Choi, Hueng-Sik | - |
dc.contributor.author | Vanacker, Jean-Marc | - |
dc.contributor.author | Moore, David D. | - |
dc.contributor.author | Giguere, Vincent | - |
dc.contributor.author | Jo, Eun-Kyeong | - |
dc.date.accessioned | 2021-06-22T19:24:37Z | - |
dc.date.available | 2021-06-22T19:24:37Z | - |
dc.date.issued | 2015-07 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.issn | 1097-4180 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/17490 | - |
dc.description.abstract | The orphan nuclear receptor estrogen-related receptor alpha (ERR alpha; NR3B1) is a key metabolic regulator, but its function in regulating inflammation remains largely unknown. Here, we demonstrate that ERRa negatively regulates Toll-like receptor (TLR)-induced inflammation by promoting Tnfaip3 transcription and fine-tuning of metabolic reprogramming in macrophages. ERR alpha-deficient (Esrra(-/-)) mice showed increased susceptibility to endo-toxin-induced septic shock, leading to more severe pro-inflammatory responses than control mice. ERR alpha regulated macrophage inflammatory responses by directly binding the promoter region of Tnfaip3, a deubiquitinating enzyme in TLR signaling. In addition, Esrra(-/-) macrophages showed an increased glycolysis, but impaired mitochondrial respiratory function and biogenesis. Further, ERR alpha was required for the regulation of NF-kappa B signaling by controlling p65 acetylation via maintenance of NAD(+) levels and sirtuin 1 activation. These findings unravel a previously unappreciated role for ERR alpha as a negative regulator of TLR-induced inflammatory responses through inducing Tnfaip3 transcription and controlling the metabolic reprogramming. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Cell Press | - |
dc.title | Orphan Nuclear Receptor ERR alpha Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.immuni.2015.07.003 | - |
dc.identifier.scopusid | 2-s2.0-84937714668 | - |
dc.identifier.wosid | 000360101100012 | - |
dc.identifier.bibliographicCitation | Immunity, v.43, no.1, pp 80 - 91 | - |
dc.citation.title | Immunity | - |
dc.citation.volume | 43 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 80 | - |
dc.citation.endPage | 91 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ESTROGEN-RELATED RECEPTOR | - |
dc.subject.keywordPlus | FATTY-ACID OXIDATION | - |
dc.subject.keywordPlus | POSTTRANSLATIONAL MODIFICATIONS | - |
dc.subject.keywordPlus | SIRTUIN 1 | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ENZYME | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | SUPPRESSOR | - |
dc.subject.keywordPlus | INFECTION | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1074761315002708?via%3Dihub | - |
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