Deoxycholate-Based Glycosides (DCGs) for Membrane Protein Stabilisation
DC Field | Value | Language |
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dc.contributor.author | Bae, Hyoung Eun | - |
dc.contributor.author | Gotfryd, Kamil | - |
dc.contributor.author | Thomas, Jennifer | - |
dc.contributor.author | Hussain, Hazrat | - |
dc.contributor.author | Ehsan, Muhammad | - |
dc.contributor.author | Go, Juyeon | - |
dc.contributor.author | Loland, Claus J. | - |
dc.contributor.author | Byrne, Bernadette | - |
dc.contributor.author | Chae, Pil Seok | - |
dc.date.accessioned | 2021-06-22T19:25:03Z | - |
dc.date.available | 2021-06-22T19:25:03Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2015-07 | - |
dc.identifier.issn | 1439-4227 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/17506 | - |
dc.description.abstract | Detergents are an absolute requirement for studying the structure of membrane proteins. However, many conventional detergents fail to stabilise denaturation-sensitive membrane proteins, such as eukaryotic proteins and membrane protein complexes. New amphipathic agents with enhanced efficacy in stabilising membrane proteins will be helpful in overcoming the barriers to studying membrane protein structures. We have prepared a number of deoxycholate-based amphiphiles with carbohydrate head groups, designated deoxycholate-based glycosides (DCGs). These DCGs are the hydrophilic variants of previously reported deoxycholate-based N-oxides (DCAOs). Membrane proteins in these agents, particularly the branched diglucoside-bearing amphiphiles DCG-1 and DCG-2, displayed favourable behaviour compared to previously reported parent compounds (DCAOs) and conventional detergents (LDAO and DDM). Given their excellent properties, these agents should have significant potential for membrane protein studies. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.title | Deoxycholate-Based Glycosides (DCGs) for Membrane Protein Stabilisation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chae, Pil Seok | - |
dc.identifier.doi | 10.1002/cbic.201500151 | - |
dc.identifier.scopusid | 2-s2.0-84934293483 | - |
dc.identifier.wosid | 000357326200011 | - |
dc.identifier.bibliographicCitation | ChemBioChem, v.16, no.10, pp.1454 - 1459 | - |
dc.relation.isPartOf | ChemBioChem | - |
dc.citation.title | ChemBioChem | - |
dc.citation.volume | 16 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1454 | - |
dc.citation.endPage | 1459 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.subject.keywordPlus | MUSCARINIC ACETYLCHOLINE-RECEPTOR | - |
dc.subject.keywordPlus | GANGLIO-TRIPOD AMPHIPHILES | - |
dc.subject.keywordPlus | GLYCOL GNG AMPHIPHILES | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | FACIAL AMPHIPHILES | - |
dc.subject.keywordPlus | COUPLED RECEPTOR | - |
dc.subject.keywordPlus | MNG AMPHIPHILES | - |
dc.subject.keywordPlus | DETERGENT | - |
dc.subject.keywordPlus | SOLUBILIZATION | - |
dc.subject.keywordPlus | CRYSTALLIZATION | - |
dc.subject.keywordAuthor | amphiphiles | - |
dc.subject.keywordAuthor | deoxycholate | - |
dc.subject.keywordAuthor | membrane proteins | - |
dc.subject.keywordAuthor | molecular design | - |
dc.subject.keywordAuthor | stabilization | - |
dc.identifier.url | https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.201500151 | - |
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