De Novo Design and Synthesis of a -Turn Peptidomimetic Scaffold and Its Application as JNK3 Allosteric Ligand
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Mi-hyun | - |
dc.contributor.author | Lee, Junghun | - |
dc.contributor.author | Hah, Jung-Mi | - |
dc.date.accessioned | 2021-06-22T19:44:58Z | - |
dc.date.available | 2021-06-22T19:44:58Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1861-4728 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/17975 | - |
dc.description.abstract | As a way to develop a neuroprotective agent for the JNK3-JIP1-binding site, peptidomimetics of JIP-1 as JNK3 allosteric regulators have been examined. The study consisted of in silico scaffold hopping, molecular docking, solution and solid-phase peptide syntheses, and K-d measurements using surface plasmon resonance. As a peptidomimetic of JIP1, heptamer mimetic 16 (K-d=2.72m) displayed a higher affinity than decamer JIP1 (K-d=23.6m). The high affinity of 16 implies that the characteristic -turn mimetic structure, phi-X-phi hydrophobic motif in 16, increased its affinity toward the JIP-site of JNK3. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | De Novo Design and Synthesis of a -Turn Peptidomimetic Scaffold and Its Application as JNK3 Allosteric Ligand | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hah, Jung-Mi | - |
dc.identifier.doi | 10.1002/asia.201403417 | - |
dc.identifier.scopusid | 2-s2.0-84930207771 | - |
dc.identifier.wosid | 000355339100010 | - |
dc.identifier.bibliographicCitation | CHEMISTRY-AN ASIAN JOURNAL, v.10, no.6, pp.1318 - 1326 | - |
dc.relation.isPartOf | CHEMISTRY-AN ASIAN JOURNAL | - |
dc.citation.title | CHEMISTRY-AN ASIAN JOURNAL | - |
dc.citation.volume | 10 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1318 | - |
dc.citation.endPage | 1326 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | JUN ACTIVATION DOMAIN | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | THERAPEUTIC TARGET | - |
dc.subject.keywordPlus | HUMAN-DISEASES | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | BINDS | - |
dc.subject.keywordAuthor | allosteric | - |
dc.subject.keywordAuthor | gamma turn | - |
dc.subject.keywordAuthor | JNK3 | - |
dc.subject.keywordAuthor | kinase inhibitors | - |
dc.subject.keywordAuthor | peptidomimetics | - |
dc.subject.keywordAuthor | scaffold hopping | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/asia.201403417 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.