Self-assembling β-glucan nanomedicine for the delivery of sirna
DC Field | Value | Language |
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dc.contributor.author | Lee, Kyungwoo | - |
dc.contributor.author | Min, Daejin | - |
dc.contributor.author | Choi, Yonghyun | - |
dc.contributor.author | Yoon, Semi | - |
dc.contributor.author | Jang, Jaehee | - |
dc.contributor.author | Hwang, Jangsun | - |
dc.contributor.author | Jeon, Hojeong | - |
dc.contributor.author | Cho, Yong Woo | - |
dc.contributor.author | Choi, Jonghoon | - |
dc.date.accessioned | 2021-06-22T09:22:14Z | - |
dc.date.available | 2021-06-22T09:22:14Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/1833 | - |
dc.description.abstract | We aimed to design and manufacture a transporter capable of delivering small interfering RNAs (siRNAs) into the skin without causing any damage. β-glucans are unique chiral polysaccharides with well-defined immunological properties and supramolecular wrapping ability. However, the chiral properties of these polymers have hardly been applied in drug delivery systems. In this study, β-glucan nanoparticles were designed and manufactured to deliver genetic material to the target cells. The β-glucan molecules were self-assembled with an siRNA into nanoparticles of 300–400 nm in diameter via a conformational transition process, in order to construct a gene delivery system. The assembled gene nanocarriers were associated with high gene-loading ability. The expression and efficiency of siRNA were verified after its delivery via β-glucan. Our results provide evidence that β-glucan nanoparticles can be effectively used to deliver siRNA into the cells. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | Self-assembling β-glucan nanomedicine for the delivery of sirna | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/biomedicines8110497 | - |
dc.identifier.scopusid | 2-s2.0-85096046717 | - |
dc.identifier.wosid | 000593501200001 | - |
dc.identifier.bibliographicCitation | Biomedicines, v.8, no.11, pp 1 - 11 | - |
dc.citation.title | Biomedicines | - |
dc.citation.volume | 8 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | ANTITUMO | - |
dc.subject.keywordPlus | RPEPTIDES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | beta-glucan | - |
dc.subject.keywordAuthor | self-assembly | - |
dc.subject.keywordAuthor | nanomedicine | - |
dc.subject.keywordAuthor | siRNA | - |
dc.subject.keywordAuthor | gene delivery | - |
dc.identifier.url | https://www.mdpi.com/2227-9059/8/11/497 | - |
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