Preparation and evaluation of 17-allyamino-17-demethoxygeldanamycin (17-AAG)-loaded poly(lactic acid-co-glycolic acid) nanoparticles
DC Field | Value | Language |
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dc.contributor.author | Pradhan, Roshan | - |
dc.contributor.author | Poudel, Bijay Kumar | - |
dc.contributor.author | Choi, Ju Yeon | - |
dc.contributor.author | Choi, Im Soon | - |
dc.contributor.author | Shin, Beom Soo | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Yong, Chul Soon | - |
dc.contributor.author | Kim, Jong Oh | - |
dc.date.accessioned | 2021-06-22T20:03:14Z | - |
dc.date.available | 2021-06-22T20:03:14Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/18363 | - |
dc.description.abstract | In the present study, we developed the novel 17-allyamino-17-demethoxygeldanamycin (17-AAG)-loaded poly(lactic acid-co-glycolic acid) (PLGA) nanoparticles (NPs) using the combination of sodium lauryl sulfate and poloxamer 407 as the anionic and non-ionic surfactant for stabilization. The PLGA NPs were prepared by emulsification/solvent evaporation method. Both the drug/polymer ratio and phase ratio were 1:10 (w/w). The optimized formulation of 17-AAG-loaded PLGA NPs had a particle size and polydispersity index of 151.6 +/- 2.0 and 0.152 +/- 0.010 nm, respectively, which was further supported by TEM image. The encapsulation efficiency and drug loading capacity were 69.9 and 7.0 %, respectively. In vitro release study showed sustained release. When in vitro release data were fitted to Korsmeyer-Peppas model, the n value was 0.468, which suggested that the drug was released by anomalous or non-Fickian diffusion. In addition, 17-AAG-loaded PLGA NPs in 72 h, displayed approximately 60 % cell viability reduction at 10 mu g/ml 17-AAG concentration, in MCF-7 cell lines, indicating sustained release from NPs. Therefore, our results demonstrated that incorporation of 17-AAG into PLGA NPs could provide a novel effective nanocarrier for the treatment of cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.title | Preparation and evaluation of 17-allyamino-17-demethoxygeldanamycin (17-AAG)-loaded poly(lactic acid-co-glycolic acid) nanoparticles | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.1007/s12272-014-0404-7 | - |
dc.identifier.scopusid | 2-s2.0-84939875987 | - |
dc.identifier.wosid | 000354299800020 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.38, no.5, pp.734 - 741 | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 38 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 734 | - |
dc.citation.endPage | 741 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001991018 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | LOADED PLGA NANOPARTICLES | - |
dc.subject.keywordPlus | BEHAVIOR IN-VITRO | - |
dc.subject.keywordPlus | PHASE-II TRIAL | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | FORMULATION | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN | - |
dc.subject.keywordPlus | ESTRADIOL | - |
dc.subject.keywordAuthor | 17-Allyamino-17-demethoxygeldanamycin | - |
dc.subject.keywordAuthor | Polylactic acid-co-glycolic acid | - |
dc.subject.keywordAuthor | Nanoparticles | - |
dc.subject.keywordAuthor | Sodium lauryl sulfate | - |
dc.subject.keywordAuthor | Poloxamer | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs12272-014-0404-7 | - |
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