Suppression of skin inflammation in keratinocytes and acute/chronic disease models by caffeic acid phenethyl ester
DC Field | Value | Language |
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dc.contributor.author | Lim, Kyung-Min | - |
dc.contributor.author | Bae, SeungJin | - |
dc.contributor.author | Koo, Jung Eun | - |
dc.contributor.author | Kim, Eun-Sun | - |
dc.contributor.author | Bae, Ok-Nam | - |
dc.contributor.author | Lee, Joo Young | - |
dc.date.accessioned | 2021-06-22T20:22:01Z | - |
dc.date.available | 2021-06-22T20:22:01Z | - |
dc.date.issued | 2015-04 | - |
dc.identifier.issn | 0340-3696 | - |
dc.identifier.issn | 1432-069X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/18759 | - |
dc.description.abstract | Skin inflammation plays a central role in the pathophysiology and symptoms of diverse chronic skin diseases including atopic dermatitis (AD). In this study, we examined if caffeic acid phenethyl ester (CAPE), a skin-permeable bioactive compound from propolis, was protective against skin inflammation using in vitro cell system and in vivo animal disease models. CAPE suppressed TNF-alpha-induced NF-kappa B activation and expression of inflammatory cytokines in human keratinocytes (HaCaT). The potency and efficacy of CAPE were superior to those of a non-phenethyl derivative, caffeic acid. Consistently, topical treatment of CAPE (0.5 %) attenuated 12-O-tetradecanoylphorbol-13-acetate(TPA)-induced skin inflammation on mouse ear as CAPE reduced ear swelling and histologic inflammation scores. CAPE suppressed increased expression of pro-inflammatory molecules such as TNF-alpha, cyclooxygenase-2 and inducible NO synthase in TPA-stimulated skin. TPA-induced phosphorylation of I kappa B and ERK was blocked by CAPE suggesting that protective effects of CAPE on skin inflammation is attributed to inhibition of NF-kappa B activation. Most importantly, in an oxazolone-induced chronic dermatitis model, topical application of CAPE (0.5 and 1 %) was effective in alleviating AD-like symptoms such as increases of trans-epidermal water loss, skin thickening and serum IgE as well as histologic inflammation assessment. Collectively, our results propose CAPE as a promising candidate for a novel topical drug for skin inflammatory diseases. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Springer Verlag | - |
dc.title | Suppression of skin inflammation in keratinocytes and acute/chronic disease models by caffeic acid phenethyl ester | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1007/s00403-014-1529-8 | - |
dc.identifier.scopusid | 2-s2.0-84925543853 | - |
dc.identifier.wosid | 000351401000003 | - |
dc.identifier.bibliographicCitation | Archives of Dermatological Research, v.307, no.3, pp 219 - 227 | - |
dc.citation.title | Archives of Dermatological Research | - |
dc.citation.volume | 307 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 219 | - |
dc.citation.endPage | 227 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | MOUSE SKIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | Caffeic acid phenethyl ester (CAPE) | - |
dc.subject.keywordAuthor | Skin inflammation | - |
dc.subject.keywordAuthor | Nuclear factor kappa B (NF-kappa B) | - |
dc.subject.keywordAuthor | Atopic dermatitis | - |
dc.subject.keywordAuthor | TPA-induced ear edema | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00403-014-1529-8 | - |
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