Shigella Outer Membrane Protein PSSP-1 Is Broadly Protective against Shigella Infectionopen access
- Authors
- Kim, Jae-Ouk; Rho, Semi; Kim, Su Hee; Kim, Heejoo; Song, Hyo Jin; Kim, Eun Jin; Kim, Ryang Yeo; Kim, Eun Hye; Sinha, Anuradha; Dey, Ayan; Yang, Jae Seung; Song, Man Ki; Nandy, Ranjan Kumar; Czerkinsky, Cecil; Kim, Dong Wook
- Issue Date
- Apr-2015
- Publisher
- AMER SOC MICROBIOLOGY
- Citation
- CLINICAL AND VACCINE IMMUNOLOGY, v.22, no.4, pp.381 - 388
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL AND VACCINE IMMUNOLOGY
- Volume
- 22
- Number
- 4
- Start Page
- 381
- End Page
- 388
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/18761
- DOI
- 10.1128/CVI.00661-14
- ISSN
- 1556-6811
- Abstract
- In developing countries, Shigella is a primary cause of diarrhea in infants and young children. Although antibiotic therapy is an effective treatment for shigellosis, therapeutic options are narrowing due to the emergence of antibiotic resistance. Thus, preventive vaccination could become the most efficacious approach for controlling shigellosis. We have identified several conserved protein antigens that are shared by multiple Shigella serotypes and species. Among these, one antigen induced cross-protection against experimental shigellosis, and we have named it pan-Shigella surface protein 1 (PSSP-1). PSSP-1-induced protection requires a mucosal administration route and coadministration of an adjuvant. When PSSP-1 was administered intranasally, it induced cross-protection against Shigella flexneri serotypes 2a, 5a, and 6, Shigella boydii, Shigella sonnei, and Shigella dysenteriae serotype 1. Intradermally administered PSSP-1 induced strong serum antibody responses but failed to induce protection in the mouse lung pneumonia model. In contrast, intranasal administration elicited efficient local and systemic antibody responses and production of interleukin 17A and gamma interferon. Interestingly, blood samples from patients with recent-onset shigellosis showed variable but significant mucosal antibody responses to other conserved Shigella protein antigens but not to PSSP-1. We suggest that PSSP-1 is a promising antigen for a broadly protective vaccine against Shigella.
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