Dose- and time-dependent expression of aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocator (ARNT) in PCB-, B[a]P-, and TBT-exposed intertidal copepod Tigriopus japonicus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Bo-Mi | - |
dc.contributor.author | Rhee, Jae-Sung | - |
dc.contributor.author | Hwang, Un-Ki | - |
dc.contributor.author | Seo, Jung Soo | - |
dc.contributor.author | Shin, Kyung-Hoon | - |
dc.contributor.author | Lee, Jae-Seong | - |
dc.date.accessioned | 2021-06-22T20:25:10Z | - |
dc.date.available | 2021-06-22T20:25:10Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 0045-6535 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/18873 | - |
dc.description.abstract | The aryl hydrocarbon receptor (AhR) and aryl hydrocarbon nuclear translocator (ARNT) genes from the copepod Tigriopus japonicus (Tj) were cloned to examine their potential functions in the invertebrate putative AhR-CYP signaling pathway. The amino acid sequences encoded by the Tj-AhR and Tj-ARNT genes showed high similarity to homologs of Daphnia and Drosophila, ranging from 68% and 70% similarity for the AhR genes to 56% for the ARNT genes. To determine whether Tj-AhR and Tj-ARNT are modulated by environmental pollutants, transcriptional expression of Tj-AhR and Tj-ARNT was analyzed in response to exposure to five concentrations of polychlorinated biphenyl (PCB 126) (control, 10, 50, 100, 500 mu g L-1), benzo[a]pyrene (B[a]P) (control, 5, 10, 50, 100 mu g L-1), and tributyltin (TBT) (control, 1, 5, 10, 20 mu g L-1) 24 h after exposure. A time-course experiment (0, 3, 6, 12, 24 h) was performed to analyze mRNA expression patterns after exposure to PCB, B[a]P, and TBT. T. japonicus exhibited dose-dependent and time-dependent upregulation of Tj-AhR and Tj-ARNT in response to pollutant exposure, and the degree of expression was dependent on the pollutant, suggesting that pollutants such as PCB, B[a]P, and TBT modulate expression of Tj-AhR and Tj-ARNT genes in the putative AhR-CYP signaling pathway. (C) 2014 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.title | Dose- and time-dependent expression of aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocator (ARNT) in PCB-, B[a]P-, and TBT-exposed intertidal copepod Tigriopus japonicus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Kyung-Hoon | - |
dc.identifier.doi | 10.1016/j.chemosphere.2014.07.099 | - |
dc.identifier.scopusid | 2-s2.0-84912071945 | - |
dc.identifier.wosid | 000348003200055 | - |
dc.identifier.bibliographicCitation | Chemosphere, v.120, pp.398 - 406 | - |
dc.relation.isPartOf | Chemosphere | - |
dc.citation.title | Chemosphere | - |
dc.citation.volume | 120 | - |
dc.citation.startPage | 398 | - |
dc.citation.endPage | 406 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.subject.keywordPlus | IMMUNOPOSITIVE PROTEINS | - |
dc.subject.keywordPlus | CYTOCHROME-P450 GENES | - |
dc.subject.keywordPlus | CYP GENES | - |
dc.subject.keywordPlus | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN | - |
dc.subject.keywordPlus | ELEGANS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | CYTOSKELETAL | - |
dc.subject.keywordPlus | XENOBIOTICS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | DIVERSITY | - |
dc.subject.keywordAuthor | Copepod | - |
dc.subject.keywordAuthor | Tigriopus japonicus | - |
dc.subject.keywordAuthor | AhR | - |
dc.subject.keywordAuthor | ARNT | - |
dc.subject.keywordAuthor | Polychlorinated biphenyl | - |
dc.subject.keywordAuthor | Benzo[a]pyrene | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0045653514010042?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.