Effect of Sodium Taurocholate on Omeprazole Buccal Adhesive Tablet: Physicochemical Characterization and Pharmacokinetics in Hamster
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Kwan Hyung | - |
dc.contributor.author | Yousaf, Abid Mehmood | - |
dc.contributor.author | Kim, Dong Wuk | - |
dc.contributor.author | Din, Fakhar Ud | - |
dc.contributor.author | Chang, Pahn-Shick | - |
dc.contributor.author | Baek, Hyung Hee | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Oh, Euichaul | - |
dc.date.accessioned | 2021-06-22T21:45:28Z | - |
dc.date.available | 2021-06-22T21:45:28Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1573-4129 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/20688 | - |
dc.description.abstract | To formulate an omeprazole buccal adhesive tablet with improved bioavailability using sodium taurocholate, omeprazole buccal adhesive tablets were prepared with sodium alginate, HPMC, magnesium oxide and different quantities of sodium taurocholate. Their physicochemical properties, such as the mucoadhesive force, stability in human saliva and release, were examined. Moreover, the absolute bioavailability was assessed by comparing the buccal administration to an omeprazole solution given intravenously to hamsters. Sodium taurocholate barely influenced the mucoadhesive force of the tablets; however, it affected the drug stability in human saliva. It positively influenced the fast drug release, but did not affect the release mechanism. In particular, omeprazole buccal adhesive tablets [omeprazole/sodium alginate/HPMC/magnesium oxide/sodium taurocholate (20/24/6/50/10 mg/tab)] showed an absolute bioavailability of about 30% in hamsters. They remained attached to the cheeks without disintegration. Moreover, they were stable in human saliva for at least 4 h. Thus, it was concluded that this omeprazole buccal adhesive tablet could be a useful possible commercial pharmaceutical product. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BENTHAM SCIENCE PUBL LTD | - |
dc.title | Effect of Sodium Taurocholate on Omeprazole Buccal Adhesive Tablet: Physicochemical Characterization and Pharmacokinetics in Hamster | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.2174/1573412911666141210215011 | - |
dc.identifier.scopusid | 2-s2.0-84930892829 | - |
dc.identifier.wosid | 000349851000004 | - |
dc.identifier.bibliographicCitation | CURRENT PHARMACEUTICAL ANALYSIS, v.11, no.2, pp.98 - 103 | - |
dc.relation.isPartOf | CURRENT PHARMACEUTICAL ANALYSIS | - |
dc.citation.title | CURRENT PHARMACEUTICAL ANALYSIS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 98 | - |
dc.citation.endPage | 103 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | LIQUID SUPPOSITORY | - |
dc.subject.keywordPlus | PERMEATION ENHANCEMENT | - |
dc.subject.keywordPlus | ORAL BIOAVAILABILITY | - |
dc.subject.keywordPlus | SALICYLIC-ACID | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | CHEEK POUCH | - |
dc.subject.keywordPlus | BILE-SALTS | - |
dc.subject.keywordPlus | ABSORPTION | - |
dc.subject.keywordPlus | VIVO | - |
dc.subject.keywordAuthor | Absolute bioavailability | - |
dc.subject.keywordAuthor | enhancer | - |
dc.subject.keywordAuthor | mucoadhesive force | - |
dc.subject.keywordAuthor | omeprazole buccal adhesive tablet | - |
dc.subject.keywordAuthor | sodium taurocholate | - |
dc.subject.keywordAuthor | stability in human saliva | - |
dc.identifier.url | https://www.eurekaselect.com/126860/article | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.