Development of Folate-Functionalized PEGylated Zein Nanoparticles for Ligand-Directed Delivery of Paclitaxel
DC Field | Value | Language |
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dc.contributor.author | Soe, Zar Chi | - |
dc.contributor.author | Ou, Wenquan | - |
dc.contributor.author | Gautam, Milan | - |
dc.contributor.author | Poudel, Kishwor | - |
dc.contributor.author | Kim, Bo Kyun | - |
dc.contributor.author | Pham, Le Minh | - |
dc.contributor.author | Phung, Cao Dai | - |
dc.contributor.author | Jeong, Jee-Heon | - |
dc.contributor.author | Jin, Sung Giu | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Ku, Sae Kwang | - |
dc.contributor.author | Yong, Chul Soon | - |
dc.contributor.author | Kim, Jong Oh | - |
dc.date.accessioned | 2021-06-22T09:25:50Z | - |
dc.date.available | 2021-06-22T09:25:50Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/2069 | - |
dc.description.abstract | In this study, we investigated the active targeted delivery of a hydrophobic drug, paclitaxel (PTX), via receptor-mediated endocytosis by folate receptors expressed on cancer cells using a protein-based nanoparticle system. PTX was loaded on zein nanoparticles and conjugated with folate (PTX/Zein-FA) to estimate its chemotherapeutic efficacy in folate receptor-expressing KB cancer cells. PTX/Zein-FA nanoparticles were successfully developed, with a nanoparticle size of similar to 180 nm and narrow polydispersity index (similar to 0.22). Accelerated release of PTX in an acidic environment was observed for PTX/Zein-FA. An in vitro cellular study of PTX/Zein-FAs in KB cells suggested that PTX/Zein-FA improved the cytotoxic activity of PTX on folate receptors overexpressed in cancer cells by inducing proapoptotic proteins and inhibiting anti-apoptotic proteins. In addition, PTX/Zein-FA exhibited anti-migratory properties and could alter the cell cycle profile of KB cells. A549 cells, which are folate receptor-negative cancer cells, showed no significant enhancement in the in vitro cellular activities of PTX/Zein-FA. We describe the antitumor efficacy of PTX/Zein-FA in KB tumor-bearing mice with minimum toxicity in healthy organs, and the results were confirmed in comparison with free drug and non-targeted nanoparticles. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | Development of Folate-Functionalized PEGylated Zein Nanoparticles for Ligand-Directed Delivery of Paclitaxel | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.3390/pharmaceutics11110562 | - |
dc.identifier.scopusid | 2-s2.0-85074471526 | - |
dc.identifier.wosid | 000502280100014 | - |
dc.identifier.bibliographicCitation | PHARMACEUTICS, v.11, no.11 | - |
dc.relation.isPartOf | PHARMACEUTICS | - |
dc.citation.title | PHARMACEUTICS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | POLYMER HYBRID NANOPARTICLES | - |
dc.subject.keywordPlus | TARGETED DELIVERY | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordPlus | FABRICATION | - |
dc.subject.keywordAuthor | folic acid | - |
dc.subject.keywordAuthor | paclitaxel | - |
dc.subject.keywordAuthor | nanoparticle | - |
dc.subject.keywordAuthor | zein | - |
dc.identifier.url | https://www.mdpi.com/1999-4923/11/11/562 | - |
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