Protective Activity of Dendropanax Morbifera Against Cisplatin-Induced Acute Kidney Injury
DC Field | Value | Language |
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dc.contributor.author | Kim, Eun-Sun | - |
dc.contributor.author | Lee, Jong Soo | - |
dc.contributor.author | Akram, Muhammad | - |
dc.contributor.author | Kim, Kyeong-A | - |
dc.contributor.author | Shin, Young-Jun | - |
dc.contributor.author | Yu, Jong-Hyun | - |
dc.contributor.author | Bae, Ok-Nam | - |
dc.date.accessioned | 2021-06-22T22:01:38Z | - |
dc.date.available | 2021-06-22T22:01:38Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 1420-4096 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/20998 | - |
dc.description.abstract | Background/Aims: Drug-induced acute kidney injury (AKI) has been a severe threat to hospitalized patients, raising the urgent needs to develop strategies to reduce AKI. We investigated the protective activity of Dendropanax morbifera (DP), a medicinal plant which has been widely used to treat infectious and pain diseases, on acute kidney injury (AKI) using cisplatin-induced nephropathic models. Methods: Both in vitro renal tubular cells (NRK-52E) and in vivo rat models were used to demonstrate the nephroprotective effect of DP. Results: Methanolic extract from DP significantly reduced cisplatin-induced toxicity in renal tubular cells. Through successive liquid extraction, the extract of DP was separated into n-hexane, CHCl3, EtOAc, n-BuOH, and H2O fractions. Among these, the CHCl3 fraction (DPCF) was found to be most potent. The protective activity of DPCF was found to be mediated through anti-oxidant, mitochondrial protective, and anti-apoptotic activities. In in vivo rat models of AKI, treatment with DPCF significantly reversed the cisplatin-induced increase in blood urea nitrogen and serum creatinine and histopathologic damage, recovered the level of anti-oxidant enzymes, and inhibited renal apoptosis. Conclusion: We demonstrated that DP extracts decreased cisplatin-induced renal toxicity, indicating its potential to ameliorate drug-associated acute kidney damage. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | S. Karger AG | - |
dc.title | Protective Activity of Dendropanax Morbifera Against Cisplatin-Induced Acute Kidney Injury | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, Ok-Nam | - |
dc.identifier.doi | 10.1159/000368466 | - |
dc.identifier.scopusid | 2-s2.0-84925408479 | - |
dc.identifier.wosid | 000351596600001 | - |
dc.identifier.bibliographicCitation | Kidney and Blood Pressure Research, v.40, no.1, pp.1 - 12 | - |
dc.relation.isPartOf | Kidney and Blood Pressure Research | - |
dc.citation.title | Kidney and Blood Pressure Research | - |
dc.citation.volume | 40 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | ACUTE TUBULAR-NECROSIS | - |
dc.subject.keywordPlus | ANTICOMPLEMENT ACTIVITY | - |
dc.subject.keywordPlus | INDUCED NEPHROTOXICITY | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | LEVEILLE | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | TRANSPORTERS | - |
dc.subject.keywordPlus | QUERCETIN | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordAuthor | Nephrotoxicity | - |
dc.subject.keywordAuthor | Cisplatin | - |
dc.subject.keywordAuthor | Acute kidney injury | - |
dc.subject.keywordAuthor | Dendropanax morbifera | - |
dc.identifier.url | https://www.karger.com/Article/FullText/368466 | - |
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