Hyaluronic acid-coated solid lipid nanoparticles for targeted delivery of vorinostat to CD44 overexpressing cancer cells
DC Field | Value | Language |
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dc.contributor.author | Tuan Hiep Tran | - |
dc.contributor.author | Choi, Ju Yeon | - |
dc.contributor.author | Ramasamy, Thiruganesh | - |
dc.contributor.author | Duy Hieu Truong | - |
dc.contributor.author | Chien Ngoc Nguyen | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Yong, Chul Soon | - |
dc.contributor.author | Kim, Jong Oh | - |
dc.date.accessioned | 2021-06-22T22:03:07Z | - |
dc.date.available | 2021-06-22T22:03:07Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2014-12 | - |
dc.identifier.issn | 0144-8617 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/21045 | - |
dc.description.abstract | Hyaluronic acid (HA)-decorated solid lipid nanoparticles (SLNs) were developed for tumor-targeted delivery of vorinostat (VRS), a histone deacetylase inhibitor. HA, a naturally occurring polysaccharide, which specifically binds to the CD44 receptor, was coated on a cationic lipid core through electrostatic interaction. After the optimization process, HA-coated VRS-loaded SLNs (HA-VRS-SLNs) were spherical, core-shell nanoparticles, with small size (similar to 100 nm), negative charge (similar to-9 mV), and narrow size distribution. In vitro release profile of HA-VRS-SLNs showed a typical bi-phasic pattern. In addition, the intracellular uptake of HA-VRS-SLNs was significantly enhanced in CD44 overexpressing cells, A549 and SCC-7 cells, but reduced when HA-VRS-SLNs were incubated with SCC-7 cells pretreated with HA or MCF-7 cells with low over-expressed CD44. Of particular importance, HA-VRS-SLNs were more cytotoxic than the free drug and VRS-SLNs in A549 and SCC-7 cells. In addition, HA shell provided longer blood circulation and reduced VRS clearance rate in rats, resulting in enhanced higher plasma concentration and bioavailability. These results clearly indicated the potential of the HA-functionalized lipid nanoparticle as a nano-sized drug formulation for chemotherapy. (C) 2014 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Hyaluronic acid-coated solid lipid nanoparticles for targeted delivery of vorinostat to CD44 overexpressing cancer cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.1016/j.carbpol.2014.08.026 | - |
dc.identifier.scopusid | 2-s2.0-84906969062 | - |
dc.identifier.wosid | 000343613800052 | - |
dc.identifier.bibliographicCitation | CARBOHYDRATE POLYMERS, v.114, pp.407 - 415 | - |
dc.relation.isPartOf | CARBOHYDRATE POLYMERS | - |
dc.citation.title | CARBOHYDRATE POLYMERS | - |
dc.citation.volume | 114 | - |
dc.citation.startPage | 407 | - |
dc.citation.endPage | 415 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | SUBEROYLANILIDE HYDROXAMIC ACID | - |
dc.subject.keywordPlus | HISTONE DEACETYLASE INHIBITOR | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | NANOCARRIERS | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordAuthor | Vorinostat | - |
dc.subject.keywordAuthor | Solid lipid nanoparticles | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.subject.keywordAuthor | Chemotherapy | - |
dc.subject.keywordAuthor | Targeting | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0144861714007954?via%3Dihub | - |
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