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Synthesis and In vivo Evaluation of 5-Methoxy-2-(phenylethynyl)quinoline (MPEQ) and [C-11]MPEQ Targeting Metabotropic Glutamate Receptor 5 (mGluR5)
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kim, Ji Young | - |
| dc.contributor.author | Son, Myung-Hee | - |
| dc.contributor.author | Choi, Kihang | - |
| dc.contributor.author | Baek, Du-Jong | - |
| dc.contributor.author | Ko, Min Kyung | - |
| dc.contributor.author | Lim, Eun Jeong | - |
| dc.contributor.author | Pae, Ae Nim | - |
| dc.contributor.author | Keum, Gyochang | - |
| dc.contributor.author | Lee, Jae Kyun | - |
| dc.contributor.author | Cho, Yong Seo | - |
| dc.contributor.author | Choo, Hyunah | - |
| dc.contributor.author | Lee, Youn Woo | - |
| dc.contributor.author | Moon, Byung Seok | - |
| dc.contributor.author | Lee, Byung Cheol | - |
| dc.contributor.author | Lee, Ho-Young | - |
| dc.contributor.author | Min, Sun-Joon | - |
| dc.date.accessioned | 2021-06-22T22:44:51Z | - |
| dc.date.available | 2021-06-22T22:44:51Z | - |
| dc.date.created | 2021-01-21 | - |
| dc.date.issued | 2014-08 | - |
| dc.identifier.issn | 0253-2964 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/22004 | - |
| dc.description.abstract | The synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl)quinoline (MPEQ) 3 as a potential mGluR5 selective radioligand is described. We have identified MPEQ 3 exhibiting the analgesic effect in the neuropathic pain animal model. The effect of mGluR5 on neuronal activity in rat brain was evaluated through FDG/PET imaging in the presence of MPEQ 3. In addition, the PET study of [C-11]MPEQ 3 proved that accumulation of [C-11]MPEQ 3 in rat brain was correlated to the localization of the mGluR5. | - |
| dc.language | 영어 | - |
| dc.language.iso | en | - |
| dc.publisher | 대한화학회 | - |
| dc.title | Synthesis and In vivo Evaluation of 5-Methoxy-2-(phenylethynyl)quinoline (MPEQ) and [C-11]MPEQ Targeting Metabotropic Glutamate Receptor 5 (mGluR5) | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Min, Sun-Joon | - |
| dc.identifier.doi | 10.5012/bkcs.2014.35.8.2304 | - |
| dc.identifier.scopusid | 2-s2.0-84906351387 | - |
| dc.identifier.wosid | 000340690600014 | - |
| dc.identifier.bibliographicCitation | Bulletin of the Korean Chemical Society, v.35, no.8, pp.2304 - 2310 | - |
| dc.relation.isPartOf | Bulletin of the Korean Chemical Society | - |
| dc.citation.title | Bulletin of the Korean Chemical Society | - |
| dc.citation.volume | 35 | - |
| dc.citation.number | 8 | - |
| dc.citation.startPage | 2304 | - |
| dc.citation.endPage | 2310 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.identifier.kciid | ART001897371 | - |
| dc.description.journalClass | 1 | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.description.journalRegisteredClass | kci | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
| dc.subject.keywordPlus | RAT MODEL | - |
| dc.subject.keywordPlus | PAIN | - |
| dc.subject.keywordPlus | LOCALIZATION | - |
| dc.subject.keywordPlus | ANTAGONIST | - |
| dc.subject.keywordPlus | ALLODYNIA | - |
| dc.subject.keywordPlus | PET | - |
| dc.subject.keywordAuthor | MPEQ | - |
| dc.subject.keywordAuthor | Metabotropic glutamate receptor 5 (mGluR5) | - |
| dc.subject.keywordAuthor | in vivo | - |
| dc.subject.keywordAuthor | PET imaging | - |
| dc.subject.keywordAuthor | Neuropathic pain | - |
| dc.identifier.url | http://koreascience.or.kr/article/JAKO201423261321701.page | - |
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Related Researcher
- Min, Sun Joon
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY (DEPARTMENT OF CHEMICAL AND MOLECULAR ENGINEERING)