Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia
- Authors
- Park, SeonJu; Nguyen Xuan Nhiem; Phan Van Kiem; Chau Van Minh; Bui Huu Tai; Kim, Nanyoung; Yoo, Hye Hyun; Song, Jae-Hyoung; Ko, Hyun-Jeong; Kim, Seung Hyun
- Issue Date
- Aug-2014
- Publisher
- Pergamon Press Ltd.
- Keywords
- Eurycoma longifolia; Quassinoid; Cytotoxicity; A549 (human lung cancer cell); HeLa (human cervical cancer cell)
- Citation
- Bioorganic and Medicinal Chemistry Letters, v.24, no.16, pp.3835 - 3840
- Indexed
- SCIE
SCOPUS
- Journal Title
- Bioorganic and Medicinal Chemistry Letters
- Volume
- 24
- Number
- 16
- Start Page
- 3835
- End Page
- 3840
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/22012
- DOI
- 10.1016/j.bmcl.2014.06.058
- ISSN
- 0960-894X
- Abstract
- Eurycoma longifolia has been widely used for various traditional medicinal purposes in South-East Asia. In this study, five new quassinoids, eurylactone E (1), eurylactone F (2), eurylactone G (3), eurycomalide D (4), and eurycomalide E (5), along with ten known quassinoids (6-15) were isolated from the roots of E. longifolia. Their structures were determined by extensive spectroscopic methods, including 1D and 2D NMR, and MS spectra data. Among the isolated compounds, 13 beta-methyl,21-dihydroeurycomanone (6) has been reported as a synthetic derivative. However, it was isolated from the natural product for the first time in this study. The cytotoxic activities of fifteen compounds were evaluated against human lung cancer cell line, A549 and human cervical cancer cell line, HeLa. (C) 2014 Elsevier Ltd. All rights reserved.
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