Synthesis and antiangiogenic activity of 6-amido-2,4,5-trimethylpyridin-3-ols
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyunji | - |
dc.contributor.author | Banskota, Suhrid | - |
dc.contributor.author | Kim, Dong-Guk | - |
dc.contributor.author | Been, Jae-Hui | - |
dc.contributor.author | Jin, You-Jin | - |
dc.contributor.author | Gautam, Jaya | - |
dc.contributor.author | Jang, Hyeonjin | - |
dc.contributor.author | Nam, Tae-Gyu | - |
dc.contributor.author | Kim, Jung-Ae | - |
dc.contributor.author | Jeong, Byeong-Seon | - |
dc.date.accessioned | 2021-06-22T23:02:47Z | - |
dc.date.available | 2021-06-22T23:02:47Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/22369 | - |
dc.description.abstract | We recently reported that 6-aminoalkyl-2,4,5-trimethylpyridin-3-ols, novel series of 6-aminopyridin-3-ol-based antioxidants, have high antiangiogenic activities. In pursuit of wider variety in the analogues, we here report the synthesis and antiangiogenic activities of 6-amidoalkyl-2,4,5-trimethylpyridin-3-ols, which would not be considered excellent antioxidants because of the poorer electron-donating effect of the C(6)-amido group than the corresponding C(6)-amino group. The selected 6-amido compounds showed up to several fold-higher antiangiogenic activities and up to an order of magnitude better antitumor activities in the chick embryo chorioallantoic membrane (CAM) assay than SU4312, a positive control. We also found that paracetamol, as a direct phenolic analogue of our simplest 6-amidopyridin-3-ol, showed a moderate level of antiangiogenic activity. We propose this study will offer a basis for a scaffold of novel angiogenesis inhibitors that can perturb angiogenesis-related pathologies. (C) 2014 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Synthesis and antiangiogenic activity of 6-amido-2,4,5-trimethylpyridin-3-ols | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Nam, Tae-Gyu | - |
dc.identifier.doi | 10.1016/j.bmcl.2014.05.005 | - |
dc.identifier.scopusid | 2-s2.0-84902553186 | - |
dc.identifier.wosid | 000338809400029 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.24, no.14, pp.3131 - 3136 | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 24 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 3131 | - |
dc.citation.endPage | 3136 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | TYROSINE KINASE-ACTIVITY | - |
dc.subject.keywordPlus | TUMOR ANGIOGENESIS | - |
dc.subject.keywordPlus | ALPHA-TOCOPHEROL | - |
dc.subject.keywordPlus | ANTIOXIDANTS | - |
dc.subject.keywordPlus | THALIDOMIDE | - |
dc.subject.keywordPlus | 6-AMINO-3-PYRIDINOLS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | REACTIVITY | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordAuthor | Amidopyridinol | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.subject.keywordAuthor | Antiangiogenic | - |
dc.subject.keywordAuthor | Antitumor | - |
dc.subject.keywordAuthor | Chick chorioallantoic membrane assay | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0960894X14004922?via%3Dihub | - |
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