Formulation and Optimization of Raloxifene-Loaded Solid Lipid Nanoparticles to Enhance Oral Bioavailability
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tran, Tuan Hiep | - |
dc.contributor.author | Ramasamy, Thiruganesh | - |
dc.contributor.author | Cho, Hyuk Jun | - |
dc.contributor.author | Kim, Yong Il | - |
dc.contributor.author | Poudel, Bijay Kumar | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Yong, Chul Soon | - |
dc.contributor.author | Kim, Jong Oh | - |
dc.date.accessioned | 2021-06-22T23:03:47Z | - |
dc.date.available | 2021-06-22T23:03:47Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 1533-4880 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/22410 | - |
dc.description.abstract | The main aim of this study was to improve the oral bioavailability of raloxifene (RXF), a selective estrogen receptor modulator, by incorporation into solid lipid nanoparticles (SLN). RXF-loaded SLN was prepared by homogenization-sonication technique and characterized through physicochemical, pharmacokinetic, and cytotoxicity studies. The optimized SLN formulation exhibited a spherical shape with average size around 140 nm, easing its transport across the lymphatic system. Augmentation in the profiles of C-max (308%) and AUC (270%) indicated a significant enhancement in the rate and extent of bioavailability by SLN formulations compared to free drug. In vitro cytotoxicity study performed in NIH-3T3 cells revealed that RXF-SLN was cytocompatible, and SLN remained unchanged during the freeze-drying process. Furthermore, the optimized formulation was quite stable at room temperature for more than two months, exemplifying its superior performance. In conclusion, SLN provides a promising platform for the pronounced enhancement of RXF bioavailability. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER SCIENTIFIC PUBLISHERS | - |
dc.title | Formulation and Optimization of Raloxifene-Loaded Solid Lipid Nanoparticles to Enhance Oral Bioavailability | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.1166/jnn.2014.8722 | - |
dc.identifier.scopusid | 2-s2.0-84901617663 | - |
dc.identifier.wosid | 000332926400008 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.14, no.7, pp.4820 - 4831 | - |
dc.relation.isPartOf | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
dc.citation.title | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
dc.citation.volume | 14 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 4820 | - |
dc.citation.endPage | 4831 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | PHYSICOCHEMICAL CHARACTERIZATION | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.subject.keywordPlus | HYDROCHLORIDE | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | SLN(TM) | - |
dc.subject.keywordPlus | SOLVENT | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordAuthor | Bioavailability | - |
dc.subject.keywordAuthor | Lymphatic Transport | - |
dc.subject.keywordAuthor | Oral Drug Delivery | - |
dc.subject.keywordAuthor | Raloxifene | - |
dc.subject.keywordAuthor | Solid Lipid Nanoparticles | - |
dc.identifier.url | https://www.ingentaconnect.com/content/asp/jnn/2014/00000014/00000007/art00008 | - |
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