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Synthesis and Biological Evaluation of 2-Substituted Quinoline 6-Carboxamides as Potential mGluR1 Antagonists for the Treatment of Neuropathic Pain
Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kim, Younghee | - |
| dc.contributor.author | Son, Jiwon | - |
| dc.contributor.author | Kim, Juhyeon | - |
| dc.contributor.author | Baek, Du-Jong | - |
| dc.contributor.author | Lee, Yong Sup | - |
| dc.contributor.author | Lim, Eun Jeong | - |
| dc.contributor.author | Lee, Jae Kyun | - |
| dc.contributor.author | Pae, Ae Nim | - |
| dc.contributor.author | Min, Sun-Joon | - |
| dc.contributor.author | Cho, Yong Seo | - |
| dc.date.accessioned | 2021-06-22T23:22:49Z | - |
| dc.date.available | 2021-06-22T23:22:49Z | - |
| dc.date.created | 2021-01-21 | - |
| dc.date.issued | 2014-06 | - |
| dc.identifier.issn | 0009-2363 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/22823 | - |
| dc.description.abstract | A series of 2-amino and 2-methoxy quinoline-6-carboxamide derivatives have been synthesized and their metabotropic glutamate receptor type 1 (mGluR1) antagonistic activities were evaluated in a functional cell-based assay. The compound 13c showed the highest potency with IC50 value of 2.16 mu m against mGluR1. Finally, in vivo evaluation of 13c in the rat spinal nerve ligation (SNL) model exhibited weak analgesic effects with regard to both mechanical allodynia and cold allodynia. | - |
| dc.language | 영어 | - |
| dc.language.iso | en | - |
| dc.publisher | Pharmaceutical Society of Japan | - |
| dc.title | Synthesis and Biological Evaluation of 2-Substituted Quinoline 6-Carboxamides as Potential mGluR1 Antagonists for the Treatment of Neuropathic Pain | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Min, Sun-Joon | - |
| dc.identifier.doi | 10.1248/cpb.c13-00945 | - |
| dc.identifier.scopusid | 2-s2.0-84903395807 | - |
| dc.identifier.wosid | 000336559100002 | - |
| dc.identifier.bibliographicCitation | Chemical and Pharmaceutical Bulletin, v.62, no.6, pp.508 - 518 | - |
| dc.relation.isPartOf | Chemical and Pharmaceutical Bulletin | - |
| dc.citation.title | Chemical and Pharmaceutical Bulletin | - |
| dc.citation.volume | 62 | - |
| dc.citation.number | 6 | - |
| dc.citation.startPage | 508 | - |
| dc.citation.endPage | 518 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
| dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
| dc.subject.keywordPlus | METABOTROPIC GLUTAMATE RECEPTORS | - |
| dc.subject.keywordPlus | GLUTAMATE-RECEPTOR-1 ANTAGONISTS | - |
| dc.subject.keywordPlus | PHARMACOLOGICAL CHARACTERIZATION | - |
| dc.subject.keywordPlus | IN-VITRO | - |
| dc.subject.keywordPlus | DERIVATIVES | - |
| dc.subject.keywordPlus | DISCOVERY | - |
| dc.subject.keywordPlus | MICE | - |
| dc.subject.keywordPlus | PROFILES | - |
| dc.subject.keywordPlus | LY456236 | - |
| dc.subject.keywordPlus | EFFICACY | - |
| dc.subject.keywordAuthor | glutamate | - |
| dc.subject.keywordAuthor | metabotropic glutamate receptor (mGluR) | - |
| dc.subject.keywordAuthor | quinoline | - |
| dc.subject.keywordAuthor | neuropathic pain | - |
| dc.subject.keywordAuthor | spinal nerve ligation (SNL) model | - |
| dc.identifier.url | https://www.jstage.jst.go.jp/article/cpb/62/6/62_c13-00945/_article | - |
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Related Researcher
- Min, Sun Joon
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY (DEPARTMENT OF CHEMICAL AND MOLECULAR ENGINEERING)