Human dopamine receptor nanovesicles for gate-potential modulators in high-performance field-effect transistor biosensors
DC Field | Value | Language |
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dc.contributor.author | Park, Seon-joo | - |
dc.contributor.author | Song, Hyun Seok | - |
dc.contributor.author | Kwon, Oh-seok | - |
dc.contributor.author | Chung, Ji-hyun | - |
dc.contributor.author | LEE, SEUNG HWAN | - |
dc.contributor.author | An, Ji-hyun | - |
dc.contributor.author | Ahn, Sae-ryun | - |
dc.contributor.author | Lee, Jieun | - |
dc.contributor.author | Yoon, Hyeonseok | - |
dc.contributor.author | Park, Tai Hyun | - |
dc.contributor.author | Jang, Jyongsik | - |
dc.date.accessioned | 2021-06-23T00:01:57Z | - |
dc.date.available | 2021-06-23T00:01:57Z | - |
dc.date.created | 2021-02-18 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/23654 | - |
dc.description.abstract | The development of molecular detection that allows rapid responses with high sensitivity and selectivity remains challenging. Herein, we demonstrate the strategy of novel bio-nanotechnology to successfully fabricate high-performance dopamine (DA) biosensor using DA Receptor-containing uniform-particle-shaped Nanovesicles-immobilized Carboxylated poly(3,4-ethylenedioxythiophene) (CPEDOT) NTs (DRNCNs). DA molecules are commonly associated with serious diseases, such as Parkinson's and Alzheimer's diseases. For the first time, nanovesicles containing a human DA receptor D1 (hDRD1) were successfully constructed from HEK-293 cells, stably expressing hDRD1. The nanovesicles containing hDRD1 as gate-potential modulator on the conducting polymer (CP) nanomaterial transistors provided high-performance responses to DA molecule owing to their uniform, monodispersive morphologies and outstanding discrimination ability. Specifically, the DRNCNs were integrated into a liquid-ion gated field-effect transistor (FET) system via immobilization and attachment processes, leading to high sensitivity and excellent selectivity toward DA in liquid state. Unprecedentedly, the minimum detectable level (MDL) from the field-induced DA responses was as low as 10â€...pM in real- time, which is 10 times more sensitive than that of previously reported CP based-DA biosensors. Moreover, the FET-type DRNCN biosensor had a rapid response time (<1â€...s) and showed excellent selectivity in human serum. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Human dopamine receptor nanovesicles for gate-potential modulators in high-performance field-effect transistor biosensors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | LEE, SEUNG HWAN | - |
dc.identifier.doi | 10.1038/srep04342 | - |
dc.identifier.scopusid | 2-s2.0-84896360769 | - |
dc.identifier.wosid | 000332534800008 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.4, pp.1 - 8 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 4 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | PROTEIN-COUPLED RECEPTORNANOTUBE HYBRID STRUCTURE | - |
dc.subject.keywordPlus | SLARGE-SCALE PRODUCTION | - |
dc.subject.keywordPlus | SELECTIVE DETECTION | - |
dc.subject.keywordPlus | ASCORBIC-ACID | - |
dc.subject.keywordPlus | FUNCTIONALIZED POLYPYRROLE | - |
dc.subject.keywordPlus | ELECTROCHEMICAL SENSOR | - |
dc.subject.keywordPlus | BIOELECTRONIC NOSE | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.identifier.url | https://www.nature.com/articles/srep04342 | - |
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