Hydroxycinnamic Acids in Crepidiastrum denticulatum Protect Oxidative Stress-Induced Retinal Damage
- Authors
- Ahn, Hong Ryul; Lee, Hee Ju; Kim, Kyung-A; Kim, Chul Young; Nho, Chu Won; Jang, Holim; Pan, Cheol-Ho; Lee, Chang Yong; Jung, Sang Hoon
- Issue Date
- Feb-2014
- Publisher
- AMER CHEMICAL SOC
- Keywords
- Crepidiastrum denticulatum; chicoric acid; glaucoma; neuroprotection; RGC-5
- Citation
- JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.62, no.6, pp.1310 - 1323
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Volume
- 62
- Number
- 6
- Start Page
- 1310
- End Page
- 1323
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/23709
- DOI
- 10.1021/jf4046232
- ISSN
- 0021-8561
- Abstract
- We investigated the effects of an ethanol extract of C. denticulatum (EECD) in a mouse model of glaucoma established by optic nerve crush (ONC), and found that EECD significantly protected against retinal ganglion cell (RGC) death caused by ONC. Furthermore, EECD effectively protected against N-methyl-D-aspartate-induced damage to the rat retinas. In vitro, EECD attenuated transformed retinal ganglion cell (RGC-5) death and significantly blunted the up-regulation of apoptotic proteins and mRNA level induced by 1-buthionine-(S,R)-sulfoximine combined with glutamate, reduced reactive oxygen species production by radical species, and inhibited lipid peroxidation. The major EECD components were found to be chicoric acid and 3,5-dicaffeoylquinic acid (3,5-DCQA) that have shown beneficial effects on retinal degeneration both in vitro and in vivo studies. Thus, EECD could be used as a natural neuroprotective agent for glaucoma, and chicoric acid and 3,5-DCQA as mark compounds for the development of functional food.
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