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Effect of alpha-resorcylic acid-L-phenylalanine amide on collagen synthesis and matrix metalloproteinase expression in fibroblasts
- Authors
- Kwak, Seon-Yeong; Noh, Jin-Mi; Lee, Suyeon; Lee, So Hun; Jeon, Su-ji; Kim, Hye-In; Kim, Jong-Ho; Lee, Yoon-Sik
- Issue Date
- Feb-2014
- Publisher
- Pergamon Press Ltd.
- Keywords
- Resorcylic acid derivative; Collagen synthesis; Suppression of MMPs expression
- Citation
- Bioorganic and Medicinal Chemistry Letters, v.24, no.3, pp.742 - 745
- Indexed
- SCIE
SCOPUS
- Journal Title
- Bioorganic and Medicinal Chemistry Letters
- Volume
- 24
- Number
- 3
- Start Page
- 742
- End Page
- 745
- ISSN
- 0960-894X
- Abstract
- Regulation of collagen synthesis and matrix metalloproteinases (MMPs) expression levels has been an important issue in medicinal, pharmaceutical and cosmetic industries. Herein, alpha-Resorcylic acid-phenylalanine amide (alpha-RA-F) was prepared and its biological activities were observed. We found that alpha-RA-F boosted collagen synthesis and reduced MMPs expression levels in human fibroblasts without cytotoxicity. (C) 2014 Elsevier Ltd. All rights reserved.
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Related Researcher
- Kim, Jong-Ho
- ERICA 공학대학 (DEPARTMENT OF MATERIALS SCIENCE AND CHEMICAL ENGINEERING)