Nanocarrier-mediated Delivery of CORM-2 Enhances Anti-allodynic and Anti-hyperalgesic Effects of CORM-2
DC Field | Value | Language |
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dc.contributor.author | Joshi, Hari Prasad | - |
dc.contributor.author | Kim, Sung Bum | - |
dc.contributor.author | Kim, Seungki | - |
dc.contributor.author | Kumar, Hemant | - |
dc.contributor.author | Jo, Min-Jae | - |
dc.contributor.author | Choi, Hyemin | - |
dc.contributor.author | Kim, Juri | - |
dc.contributor.author | Kyung, Jae Won | - |
dc.contributor.author | Sohn, Seil | - |
dc.contributor.author | Kim, Kyoung-Tae | - |
dc.contributor.author | Kim, Jin-Ki | - |
dc.contributor.author | Han, In-Bo | - |
dc.date.accessioned | 2021-06-22T09:42:59Z | - |
dc.date.available | 2021-06-22T09:42:59Z | - |
dc.date.issued | 2019-08 | - |
dc.identifier.issn | 0893-7648 | - |
dc.identifier.issn | 1559-1182 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/2404 | - |
dc.description.abstract | Neuropathic pain is a devastating chronic condition and effective treatments are still lacking. Carbon monoxide-releasing molecule-2 (CORM-2) as a carbon monoxide (CO) carrier, exerts potent anti-neuropathic pain effects; however, its poor water solubility and short half-life hinder its clinical utility. Therefore, the aim of this study was to investigate whether CORM-2-loaded solid lipid nanoparticles (CORM-2-SLNs) enhance the anti-allodynic and anti-hyperalgesic effects of CORM-2 in a rat chronic constriction injury (CCI) model. CORM-2-SLNs were prepared using a nanotemplate engineering technique with slight modifications. The physiochemical properties of CORM-2-SLNs were characterized and CO release from CORM-2-SLNs was assessed using a myoglobin assay. CO was slowly released from CORM-2-SLNs, was observed, and the half-life of CO release was 50 times longer than that of CORM-2. In vivo results demonstrate that intraperitoneal administration of CORM-2-SLNs (5 and 10mg/kg/day, ip) once daily for seven consecutive days significantly reduced the mechanical allodynia and mechanical hyperalgesia compared with CORM-2 (10mg/kg/day, ip). RT-PCR and Western blot analyses on days 7 and 14, revealed that treatment with CORM-2-SLNs resulted in greater reductions in the CCI-elevated levels of heme-oxygenase-2 (HO-2); inducible nitric oxide synthase (iNOS); neuronal NOS (nNOS); and inflammatory mediators (TNF-alpha, IBA-1, and GFAP) in the spinal cord and dorsal root ganglions compared with treatment with CORM-2. In contrast, HO-1 and IL-10 were significantly increased in the CORM-2-SLN-treated group compared with the group treated with CORM-2. These data indicate that CORM-2-SLNs are superior to CORM-2-S in alleviating mechanical allodynia and mechanical hyperalgesia. | - |
dc.format.extent | 16 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER | - |
dc.title | Nanocarrier-mediated Delivery of CORM-2 Enhances Anti-allodynic and Anti-hyperalgesic Effects of CORM-2 | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1007/s12035-019-1468-7 | - |
dc.identifier.scopusid | 2-s2.0-85068811363 | - |
dc.identifier.wosid | 000475673100020 | - |
dc.identifier.bibliographicCitation | MOLECULAR NEUROBIOLOGY, v.56, no.8, pp 5539 - 5554 | - |
dc.citation.title | MOLECULAR NEUROBIOLOGY | - |
dc.citation.volume | 56 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 5539 | - |
dc.citation.endPage | 5554 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | MONOXIDE-RELEASING MOLECULES | - |
dc.subject.keywordPlus | SOLID LIPID NANOPARTICLES | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | CARBON-MONOXIDE | - |
dc.subject.keywordPlus | NEUROPATHIC PAIN | - |
dc.subject.keywordPlus | SUSTAINED-RELEASE | - |
dc.subject.keywordPlus | GLIAL ACTIVATION | - |
dc.subject.keywordPlus | HEME OXYGENASE-1 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Neuropathic pain | - |
dc.subject.keywordAuthor | Nanoparticles | - |
dc.subject.keywordAuthor | Allodynia | - |
dc.subject.keywordAuthor | Hyperalgesia | - |
dc.subject.keywordAuthor | Carbon monoxide releasing molecule | - |
dc.subject.keywordAuthor | Carbon monoxide | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs12035-019-1468-7 | - |
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