A mouse polyomavirus-encoded microRNA targets the cellular apoptosis pathway through Smad2 inhibition
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sung, C.K. | - |
dc.contributor.author | Yim, H. | - |
dc.contributor.author | Andrews, E. | - |
dc.contributor.author | Benjamin, T.L. | - |
dc.date.accessioned | 2021-06-23T01:23:47Z | - |
dc.date.available | 2021-06-23T01:23:47Z | - |
dc.date.created | 2021-01-22 | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 0042-6822 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/25449 | - |
dc.description.abstract | Some viruses and most eukaryotic cells have microRNAs that regulate the expression of many genes. Although many viral miRNAs have been identified, only a few have been included in in vivo functional studies. Here we show that a Py-encoded miRNA downregulates the expression of the pro-apoptotic factor Smad2, resulting in the suppression of the apoptosis pathway. To study the Py miRNA in an in vivo context, a miRNA-deficient mutant virus was created on the background of the LID virus strain which establishes a rapid and lethal infection in newborn mice. Apoptosis analysis on kidney tissues indicates that the pro-apoptotic pathway is targeted in the infected host as well. Suppression of apoptosis through targeting of Smad2 by the Py miRNA is expected to synergize with anti-apoptotic effects previously attributed to the polyoma tumor antigens in support of virus replication in the natural host. © 2014 Elsevier Inc. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Academic Press Inc. | - |
dc.title | A mouse polyomavirus-encoded microRNA targets the cellular apoptosis pathway through Smad2 inhibition | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yim, H. | - |
dc.identifier.doi | 10.1016/j.virol.2014.07.052 | - |
dc.identifier.scopusid | 2-s2.0-84906280101 | - |
dc.identifier.wosid | 000344434400007 | - |
dc.identifier.bibliographicCitation | Virology, v.468, pp.57 - 62 | - |
dc.relation.isPartOf | Virology | - |
dc.citation.title | Virology | - |
dc.citation.volume | 468 | - |
dc.citation.startPage | 57 | - |
dc.citation.endPage | 62 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordPlus | HOST-RANGE | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | TRANSFORMATION | - |
dc.subject.keywordPlus | DETERMINANT | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | P150(SAL2) | - |
dc.subject.keywordPlus | MUTANTS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | Mouse polyomavirus | - |
dc.subject.keywordAuthor | MicroRNA | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Smad2 a cellular target | - |
dc.subject.keywordAuthor | Animal infection | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0042682214003699?via%3Dihub | - |
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