SUCCINCT SYNTHESIS OF BOSENTAN UTILIZING GLYCOL MONO-THP ETHER
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Chung Ryul | - |
dc.contributor.author | Lee, Sang Yeul | - |
dc.contributor.author | Nam, Tae-gyu | - |
dc.date.accessioned | 2021-06-23T01:44:41Z | - |
dc.date.available | 2021-06-23T01:44:41Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 0039-7911 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/25902 | - |
dc.description.abstract | A concise synthetic method for bosentan, a nonpeptide orally active dual endothelin (ET-1(A/B)) receptor antagonist used for the treatment of pulmonary artery hypertension (PAH), was developed. We developed a new succinct synthetic route for bosentan by employing an acid-labile tetrahydropyran (THP)-protected glycol. THP group is advantageous over the previously known protection groups used in bosentan synthesis in that it provides a clean and quantitative deprotection. Bosentan was constructed via two parallel reaction pathways, yet the better product yield was obtained from a pathway via 6. Deprotection of THP ether was achieved under a mild acidic condition to afford bosentan. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.title | SUCCINCT SYNTHESIS OF BOSENTAN UTILIZING GLYCOL MONO-THP ETHER | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Nam, Tae-gyu | - |
dc.identifier.doi | 10.1080/00397911.2014.904881 | - |
dc.identifier.scopusid | 2-s2.0-84904405608 | - |
dc.identifier.wosid | 000340109900005 | - |
dc.identifier.bibliographicCitation | SYNTHETIC COMMUNICATIONS, v.44, no.17, pp.2488 - 2493 | - |
dc.relation.isPartOf | SYNTHETIC COMMUNICATIONS | - |
dc.citation.title | SYNTHETIC COMMUNICATIONS | - |
dc.citation.volume | 44 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 2488 | - |
dc.citation.endPage | 2493 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | ENDOTHELIN | - |
dc.subject.keywordPlus | HYPERTENSION | - |
dc.subject.keywordAuthor | Bosentan | - |
dc.subject.keywordAuthor | endothelin receptor antagonist | - |
dc.subject.keywordAuthor | pulmonary arterial hypertension | - |
dc.subject.keywordAuthor | tetrahydropyran ether | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/00397911.2014.904881 | - |
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