Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jalani, Ghulam | - |
dc.contributor.author | Jung, Chan Woo | - |
dc.contributor.author | Lee, Jae Sang | - |
dc.contributor.author | Lim, Dong Woo | - |
dc.date.accessioned | 2021-06-23T01:45:13Z | - |
dc.date.available | 2021-06-23T01:45:13Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2014-05 | - |
dc.identifier.issn | 1176-9114 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/25920 | - |
dc.description.abstract | Stimuli-responsive, polymer-based nanostructures with anisotropic compartments are of great interest as advanced materials because they are capable of switching their shape via environmentally-triggered conformational changes, while maintaining discrete compartments. In this study, a new class of stimuli-responsive, anisotropic nanofiber scaffolds with physically and chemically distinct compartments was prepared via electrohydrodynamic cojetting with sideby- side needle geometry. These nanofibers have a thermally responsive, physically-crosslinked compartment, and a chemically-crosslinked compartment at the nanoscale. The thermally responsive compartment is composed of physically crosslinkable poly(N-isopropylacrylamide) poly(NIPAM) copolymers, and poly(NIPAM-co-stearyl acrylate) poly(NIPAM-co-SA), while the thermally-unresponsive compartment is composed of polyethylene glycol dimethacrylates. The two distinct compartments were physically crosslinked by the hydrophobic interaction of the stearyl chains of poly(NIPAM-co-SA) or chemically stabilized via ultraviolet irradiation, and were swollen in physiologically relevant buffers due to their hydrophilic polymer networks. Bicompartmental nanofibers with the physically-crosslinked network of the poly(NIPAM-co-SA) compartment showed a thermally-triggered shape change due to thermally-induced aggregation of poly(NIPAM-co-SA). Furthermore, when bovine serum albumin and dexamethasone phosphate were separately loaded into each compartment, the bicompartmental nanofibers with anisotropic actuation exhibited decoupled, controlled release profiles of both drugs in response to a temperature. A new class of multicompartmental nanofibers could be useful for advanced nanofiber scaffolds with two or more drugs released with different kinetics in response to environmental stimuli. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.title | Fabrication and characterization of anisotropic nanofiber scaffolds for advanced drug delivery systems | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Dong Woo | - |
dc.identifier.doi | 10.2147/IJN.S51842 | - |
dc.identifier.scopusid | 2-s2.0-84900402440 | - |
dc.identifier.wosid | 000349961100005 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v.9, no.SUPPL.1, pp.33 - 49 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.title | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.volume | 9 | - |
dc.citation.number | SUPPL.1 | - |
dc.citation.startPage | 33 | - |
dc.citation.endPage | 49 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ELECTROSPUN NANOFIBERS | - |
dc.subject.keywordPlus | WETTABILITY | - |
dc.subject.keywordPlus | ACTUATION | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | FIBERS | - |
dc.subject.keywordPlus | SHAPE | - |
dc.subject.keywordAuthor | stimuli responsiveness | - |
dc.subject.keywordAuthor | anisotropy | - |
dc.subject.keywordAuthor | nanofibers | - |
dc.subject.keywordAuthor | actuation | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | tissue engineering | - |
dc.identifier.url | https://www.dovepress.com/fabrication-and-characterization-of-anisotropic-nanofiber-scaffolds-fo-peer-reviewed-fulltext-article-IJN | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.