Development of docetaxel-loaded solid self-nanoemulsifying drug delivery system (SNEDDS) for enhanced chemotherapeutic effect
DC Field | Value | Language |
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dc.contributor.author | Seo, Youn Gee | - |
dc.contributor.author | Kim, Dae Hwan | - |
dc.contributor.author | Ramasamy, Thiruganesh | - |
dc.contributor.author | Kim, Jeong Hwan | - |
dc.contributor.author | Marasini, Nirmal | - |
dc.contributor.author | Oh, Yu-Kyoung | - |
dc.contributor.author | Kim, Dong-Wuk | - |
dc.contributor.author | Kim, Jin Ki | - |
dc.contributor.author | Yong, Chul Soon | - |
dc.contributor.author | Kim, Jong Oh | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.date.accessioned | 2021-06-23T02:44:50Z | - |
dc.date.available | 2021-06-23T02:44:50Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/27173 | - |
dc.description.abstract | The main purpose of this study was to investigate the potential of self-nano-emulsifying drug delivery system (SNEDDS) in improving the bioavailability of docetaxel (DCT) and its chemotherapeutic effect. The DCT-loaded SNEDDS was prepared by employing rational blends of capryol 90, labrasol, and transcutol HP using ternary phase diagram. The liquid nano-emulsion was spray-dried into solid SNEDDS (D-SNEDDS) using an inert porous carrier, colloidal silica. The optimized formulation was characterized in terms of physico-chemical and pharmacokinetic parameters. Furthermore, anti-tumor efficacy of D-SNEDDS was compared with commercial marketed product, Taxotere (R). The various compositions of SNEDDS were screened and found optimal at a volume ratio of 10/75/15 for capryol 90, labrasol, and transcutol HP, respectively. We observed a high oral bioavailability of 17% DCT for D-SNEDDS than compared to only 2.6% for pure DCT solution. Notably, D-SNEDDS exhibited an augmented anti-tumor efficacy with a reduced toxicity profile when compared with intravenously administered Taxotere (R), the commercialized formulation of DCT. Taken together, D-SNEDDS could be a potential candidate for an oral dosage form of DCT with enhanced antitumor activity and reduced toxicity. (C) 2013 Elsevier B. V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.title | Development of docetaxel-loaded solid self-nanoemulsifying drug delivery system (SNEDDS) for enhanced chemotherapeutic effect | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wuk | - |
dc.contributor.affiliatedAuthor | Kim, Jin Ki | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.1016/j.ijpharm.2013.05.034 | - |
dc.identifier.scopusid | 2-s2.0-84883865017 | - |
dc.identifier.wosid | 000321496200048 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.452, no.1-2, pp.412 - 420 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.citation.title | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.citation.volume | 452 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 412 | - |
dc.citation.endPage | 420 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | IN-VITRO EVALUATION | - |
dc.subject.keywordPlus | ORAL BIOAVAILABILITY | - |
dc.subject.keywordPlus | PHYSICOCHEMICAL CHARACTERIZATION | - |
dc.subject.keywordPlus | MICROEMULSIFYING FORMULATION | - |
dc.subject.keywordPlus | INTESTINAL-ABSORPTION | - |
dc.subject.keywordPlus | VIVO EVALUATION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | OPTIMIZATION | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | SUPPOSITORY | - |
dc.subject.keywordAuthor | Anti-tumor efficacy | - |
dc.subject.keywordAuthor | Bioavailability | - |
dc.subject.keywordAuthor | Docetaxel | - |
dc.subject.keywordAuthor | Self-nanoemulsifying drug delivery systems | - |
dc.subject.keywordAuthor | Toxicity | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0378517313004377?via%3Dihub | - |
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