Docetaxel-Loaded Polylactic Acid-Co-Glycolic Acid Nanoparticles: Formulation, Physicochemical Characterization and Cytotoxicity Studies
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pradhan, Roshan | - |
dc.contributor.author | Poudel, Bijay Kumar | - |
dc.contributor.author | Ramasamy, Thiruganesh | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.contributor.author | Yong, Chul Soon | - |
dc.contributor.author | Kim, Jong Oh | - |
dc.date.accessioned | 2021-06-23T02:45:25Z | - |
dc.date.available | 2021-06-23T02:45:25Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 1533-4880 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/27192 | - |
dc.description.abstract | In the present study, we developed novel docetaxel (DTX)-loaded polylactic acid-co-glycolic acid (PLGA) nanoparticles (NPs) using the combination of sodium lauryl sulfate (SLS) and poloxamer 407, the anionic and non-ionic surfactants respectively for stabilization. The NPs were prepared by emulsification/solvent evaporation method. The combination of these surfactants at weight ratio of 1:0.5 was able to produce uniformly distributed small sized NPs and demonstrated the better stability of NP dispersion with high encapsulation efficiency (85.9 +/- 0.6%). The drug/polymer ratio and phase ratio were 2:10 and 1:10, respectively. The optimized formulation of DTX-loaded PLGA NPs had a particle size and polydispersity index of 104.2 +/- 1.5 nm and 0.152 +/- 0.006, respectively, which was further supported by TEM image. In vitro release study was carried out with dialysis membrane and showed 32% drug release in 192 h. When in vitro release data were fitted to Korsmeyer-Peppas model, the n value was 0.481, which suggested the drug was released by anomalous or non-Fickian diffusion. In addition, DTX-loaded PLGA NPs in 72 h, displayed approximately 75% cell viability reduction at 10 mu g/ml DTX concentration, in MCF-7 cell lines, indicating sustained release from NPs. Therefore, our results demonstrated that incorporation of DTX into PLGA NPs could provide a novel effective nanocarrier for the treatment of cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER SCIENTIFIC PUBLISHERS | - |
dc.title | Docetaxel-Loaded Polylactic Acid-Co-Glycolic Acid Nanoparticles: Formulation, Physicochemical Characterization and Cytotoxicity Studies | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.1166/jnn.2013.7735 | - |
dc.identifier.scopusid | 2-s2.0-84883395148 | - |
dc.identifier.wosid | 000320632200119 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.13, no.8, pp.5948 - 5956 | - |
dc.relation.isPartOf | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
dc.citation.title | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
dc.citation.volume | 13 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 5948 | - |
dc.citation.endPage | 5956 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | BEHAVIOR IN-VITRO | - |
dc.subject.keywordPlus | PHASE-II TRIAL | - |
dc.subject.keywordPlus | PLGA NANOPARTICLES | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | ESTRADIOL | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordAuthor | Docetaxel | - |
dc.subject.keywordAuthor | Polylactic Acid-Co-Glycolic Acid | - |
dc.subject.keywordAuthor | Nanoparticles | - |
dc.subject.keywordAuthor | Sodium Lauryl Sulfate | - |
dc.subject.keywordAuthor | Poloxamer | - |
dc.identifier.url | https://www.ingentaconnect.com/content/asp/jnn/2013/00000013/00000008/art00119;jsessionid=99a0ifqhkhhf2.x-ic-live-02 | - |
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