Quantum dot-assembled nanoparticles with polydiacetylene supramolecule toward label-free, multiplexed optical detection
- Authors
- Kyeong, San; Kang, Homan; Yim, Joonhyuk; Jeon, Su-Ji; Jeong, Cheol Hwan; Lee, Yoon-Sik; Jun, Bong-Hyun; Kim, Jong-Ho
- Issue Date
- Mar-2013
- Publisher
- Academic Press
- Keywords
- Label-free detection; Multiplexed detection; Optical biosensor; Polydiacetylene; Quantum dots
- Citation
- Journal of Colloid and Interface Science, v.394, pp.44 - 48
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Colloid and Interface Science
- Volume
- 394
- Start Page
- 44
- End Page
- 48
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/28787
- DOI
- 10.1016/j.jcis.2012.11.039
- ISSN
- 0021-9797
- Abstract
- Quantum dot (QD)-assembled silica nanoparticles bearing a polydiacetylene (PDA) supramolecule on their surface (SiO2@QDs@PDA NPs) were developed for label-free and multiplexed detection of biological molecules. Two types of QD-assembled silica NPs (SiO2@QDs NPs) were prepared and coated with the PDA supramolecule via photo-induced polymerization of 10,12-pentacosadiynoic acid. One of the SiO2@QDs NPs was embedded with blue-QDs, and the other was embedded with green-QDs for encoding. The resulting SiO2@QDs@PDA NPs showed discrete QD photoluminescence for encoding as well as PDA fluorescence for sensing a target without interference or overlap. Under heating stress of the SiO2@QDs@PDA NPs, the color of the PDA changed from blue to red, which allowed us to observe the fluorescence emitted from red PDA. The mixture of two different SiO2@QDs@PDA NPs, SiO2@QDs@blue-PDA NPs not emitting the fluorescence of PDA and SiO2@QDs@red-PDA NPs where stress was brought onto turn on the PDA fluorescence, was effectively imaged and readily distinguished via fluorescence microscopy, indicating their potential for label-free and multiplexed detection of target molecules. (C) 2012 Elsevier Inc. All rights reserved.
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