3D-QSAR studies of 1,2-diaryl-1H-benzimidazole derivatives as JNK3 inhibitors with protective effects in neuronal cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Mi-hyun | - |
dc.contributor.author | Ryu, Jae-Sang | - |
dc.contributor.author | Hah, Jung-Mi | - |
dc.date.accessioned | 2021-06-23T04:02:05Z | - |
dc.date.available | 2021-06-23T04:02:05Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2013-03 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/28788 | - |
dc.description.abstract | JNKs (c-Jun N-terminal kinases) have the potential to serve as a therapeutic target for various inflammatory, vascular, neurodegenerative, metabolic and oncological diseases. In particular, ATP-competitive JNK3 inhibitors act as neuroprotective agents. Here we introduce 1,2-diaryl-1H-benzimidazole derivatives as selective JNK3 inhibitors from among our in-house compounds and describe our elucidation of their SAR using 3D-QSAR models. A predictive CoMFA model (q(2) = 0.795, r(2) = 0.931) and a CoMSIA model (q(2) = 0.700, r(2) = 0.937) were used to describe the non-linearly combined affinity of each functional group in the inhibitors. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | 3D-QSAR studies of 1,2-diaryl-1H-benzimidazole derivatives as JNK3 inhibitors with protective effects in neuronal cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hah, Jung-Mi | - |
dc.identifier.doi | 10.1016/j.bmcl.2013.01.082 | - |
dc.identifier.scopusid | 2-s2.0-84874663812 | - |
dc.identifier.wosid | 000315331500013 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.23, no.6, pp.1639 - 1642 | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 23 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1639 | - |
dc.citation.endPage | 1642 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | N-TERMINAL KINASE | - |
dc.subject.keywordAuthor | 1,2-Diaryl-1H-benzimidazole | - |
dc.subject.keywordAuthor | Neuroprotective agents | - |
dc.subject.keywordAuthor | JNK inhibitors | - |
dc.subject.keywordAuthor | 3D-QSAR | - |
dc.subject.keywordAuthor | Receptor-guided alignment | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0960894X13001157?via%3Dihub | - |
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