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Synthesis and biological evaluation of 2-(arylethynyl)quinoline derivatives as mGluR5 antagonists for the treatment of neuropathic pain
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Son, Myung-Hee | - |
| dc.contributor.author | Kim, Ji Young | - |
| dc.contributor.author | Lim, Eun Jeong | - |
| dc.contributor.author | Baek, Du-Jong | - |
| dc.contributor.author | Choi, Kihang | - |
| dc.contributor.author | Lee, Jae Kyun | - |
| dc.contributor.author | Pae, Ae Nim | - |
| dc.contributor.author | Min, Sun-Joon | - |
| dc.contributor.author | Cho, Yong Seo | - |
| dc.date.accessioned | 2021-06-23T04:02:17Z | - |
| dc.date.available | 2021-06-23T04:02:17Z | - |
| dc.date.issued | 2013-03 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.issn | 1464-3405 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/28795 | - |
| dc.description.abstract | We described here the synthesis and biological evaluation of mGluR5 antagonists containing a quinoline ring structure. Using intracellular calcium mobilization assay (FDSS assay), we identified compound 5n, showing high inhibitory activity against mGluR5. In addition, it was found that compound 5n has excellent stability profile. Finally, this compound exhibited favorable analgesic effects in spinal nerve ligation model of neuropathic pain, which is comparable to gabapentin. (c) 2012 Elsevier Ltd. All rights reserved. | - |
| dc.format.extent | 5 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | Pergamon Press Ltd. | - |
| dc.title | Synthesis and biological evaluation of 2-(arylethynyl)quinoline derivatives as mGluR5 antagonists for the treatment of neuropathic pain | - |
| dc.type | Article | - |
| dc.publisher.location | 영국 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2012.12.056 | - |
| dc.identifier.scopusid | 2-s2.0-84873744551 | - |
| dc.identifier.wosid | 000314693400064 | - |
| dc.identifier.bibliographicCitation | Bioorganic and Medicinal Chemistry Letters, v.23, no.5, pp 1472 - 1476 | - |
| dc.citation.title | Bioorganic and Medicinal Chemistry Letters | - |
| dc.citation.volume | 23 | - |
| dc.citation.number | 5 | - |
| dc.citation.startPage | 1472 | - |
| dc.citation.endPage | 1476 | - |
| dc.type.docType | Article | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | sci | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.subject.keywordPlus | METABOTROPIC GLUTAMATE RECEPTORS | - |
| dc.subject.keywordPlus | RAT MODEL | - |
| dc.subject.keywordPlus | 2-METHYL-6-(PHENYLETHYNYL)-PYRIDINE MPEP | - |
| dc.subject.keywordPlus | ALLOSTERIC MODULATORS | - |
| dc.subject.keywordPlus | POTENT | - |
| dc.subject.keywordPlus | ALLODYNIA | - |
| dc.subject.keywordPlus | COGNITION | - |
| dc.subject.keywordPlus | DISEASE | - |
| dc.subject.keywordPlus | ANXIETY | - |
| dc.subject.keywordAuthor | Metabotropic glutamate receptor | - |
| dc.subject.keywordAuthor | Antagonist | - |
| dc.subject.keywordAuthor | Quinoline | - |
| dc.subject.keywordAuthor | Sonogashira reaction | - |
| dc.subject.keywordAuthor | Neuropathic pain | - |
| dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0960894X12016502?via%3Dihub | - |
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Related Researcher
- Min, Sun Joon
- ERICA 공학대학 (ERICA 에너지바이오학과)