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Global Phylogeny of Shigella sonnei Strains from Limited Single Nucleotide Polymorphisms (SNPs) and Development of a Rapid and Cost-Effective SNP-Typing Scheme for Strain Identification by High-Resolution Melting Analysisopen access
- Authors
- Sangal, Vartul; Holt, Kathryn E.; Yuan, Jianfeng; Brown, Derek J.; Filliol-Toutain, Ingrid; Weill, Francois-Xavier; Kim, Dong-Wook; da Silveira, Wanderley Dias; Pickard, Derek; Thomson, Nicholas R.; Parkhill, Julian; Yu, Jun
- Issue Date
- Jan-2013
- Publisher
- AMER SOC MICROBIOLOGY
- Keywords
- KOREA; ANTIMICROBIAL RESISTANCE
- Citation
- JOURNAL OF CLINICAL MICROBIOLOGY, v.51, no.1, pp 303 - 305
- Pages
- 3
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- JOURNAL OF CLINICAL MICROBIOLOGY
- Volume
- 51
- Number
- 1
- Start Page
- 303
- End Page
- 305
- ISSN
- 0095-1137
1098-660X
- Abstract
- The current Shigella sonnei pandemic involves geographically associated, multidrug-resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited single nucleotide polymorphisms (SNPs). By typing 6 informative SNPs using a high-resolution melting (HRM) assay, major S. sonnei lineages/sublineages can be identified as defined by whole-genome variation.
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Related Researcher
- KIM, Dong Wook
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)