Metabolic profile determination of 25N-NBOMe in human liver microsomes by liquid chromatography-quadrupole time-of-flight mass spectrometry
DC Field | Value | Language |
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dc.contributor.author | Seo, Hyewon | - |
dc.contributor.author | Kim, In Sook | - |
dc.contributor.author | Kim, Young-Hoop | - |
dc.contributor.author | Yoo, Hye Hyun | - |
dc.contributor.author | Hong, Jin | - |
dc.date.accessioned | 2021-06-22T10:03:14Z | - |
dc.date.available | 2021-06-22T10:03:14Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.issn | 0937-9827 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/2983 | - |
dc.description.abstract | 2-(2,5-Dimethoxy-4-nitrophenyl)-N-(2-methoxybenzyl)ethanamine (25N-NBOMe, 2C-N-NBOMe, NBOMe-2C-N) is a novel synthetic psychoactive substance of the phenethylamine chemical class. A few metabolism studies have been conducted for 25I-NBOMe, 25B-NBOMe, and 25C-NBOMe, and others, whereas 25N-NBOMe metabolism has not been researched. In this study, the in vitro metabolism of 25N-NBOMe was investigated with human liver microsomes, and the reaction mixture was analyzed using liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS). Formation of 14 metabolites (M1-M14) was yielded with incubation of 25N-NBOMe in human liver microsomes in the presence of NADPH. The metabolites were structurally characterized on the basis of accurate mass analysis and MS/MS fragmentation patterns. The biotransformations included hydroxylation, O-demethylation, N-dealkylation, nitro reduction, dehydrogenation, carbonylation, and combinations thereof. Hydroxyl metabolite was the most abundant compound after the phase I process. These results provide helpful information establishing biomarkers in case of 25N-NBOMe ingestion. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | Metabolic profile determination of 25N-NBOMe in human liver microsomes by liquid chromatography-quadrupole time-of-flight mass spectrometry | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Hye Hyun | - |
dc.identifier.doi | 10.1007/s00414-018-1904-7 | - |
dc.identifier.scopusid | 2-s2.0-85051492325 | - |
dc.identifier.wosid | 000464848100023 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF LEGAL MEDICINE, v.133, no.3, pp.833 - 841 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF LEGAL MEDICINE | - |
dc.citation.title | INTERNATIONAL JOURNAL OF LEGAL MEDICINE | - |
dc.citation.volume | 133 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 833 | - |
dc.citation.endPage | 841 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Legal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Legal | - |
dc.subject.keywordPlus | RAT URINE | - |
dc.subject.keywordPlus | 25I-NBOME | - |
dc.subject.keywordPlus | MS/MS | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordPlus | MS | - |
dc.subject.keywordAuthor | 25N-NBOMe | - |
dc.subject.keywordAuthor | Human liver microsomes | - |
dc.subject.keywordAuthor | Metabolism | - |
dc.subject.keywordAuthor | LC-Q-TOF/MS | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00414-018-1904-7 | - |
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