The Evaluation of CP-001 (a Standardized Herbal Mixture of Houttuynia cordata, Rehmannia glutinosa, Betula platyphylla, and Rubus coreanus) for Cytochrome P450-Related Herb-Drug Interactions
DC Field | Value | Language |
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dc.contributor.author | Yoo, Hye Hyun | - |
dc.contributor.author | Kim, Sun-A | - |
dc.contributor.author | Kim, In Sook | - |
dc.contributor.author | Ko, Seong-Gyu | - |
dc.date.accessioned | 2021-06-23T05:44:05Z | - |
dc.date.available | 2021-06-23T05:44:05Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2013-07 | - |
dc.identifier.issn | 1741-427X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/30962 | - |
dc.description.abstract | In the present study, the effect of CP-001, a standardized herbal mixture of Houttuynia cordata, Rehmannia glutinosa, Betula platyphylla, and Rubus coreanus, on cytochrome P450 (CYP) enzyme-mediated drug metabolism was investigated in vitro to evaluate the potential for herb-drug interactions. CP-001 was tested at concentrations of 1, 3, 10, 30, and 100 mu g/mL. A CYP-specific substrate mixture was incubated with CP-001 in human liver microsomes, and the metabolites generated by each CYP-specific metabolic reaction were measured by liquid chromatography-tandem mass spectrometry. CP-001 seemed to slightly inhibit some CYP isozymes, but the IC50 values for all CYP isozymes were greater than 100 mu g/mL. Furthermore, CP-001 did not exhibit time-dependent CYP inhibitory activities, indicating that it does not act as a mechanism-based inactivator of CYP enzymes. In conclusion, the effects of CP-001 on CYP isozyme activities were negligible at the concentrations tested. Therefore, the likelihood of herbal mixture-drug interaction is considered minimal. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Oxford University Press | - |
dc.title | The Evaluation of CP-001 (a Standardized Herbal Mixture of Houttuynia cordata, Rehmannia glutinosa, Betula platyphylla, and Rubus coreanus) for Cytochrome P450-Related Herb-Drug Interactions | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Hye Hyun | - |
dc.identifier.doi | 10.1155/2013/824270 | - |
dc.identifier.scopusid | 2-s2.0-84880872048 | - |
dc.identifier.wosid | 000321833900001 | - |
dc.identifier.bibliographicCitation | Evidence-based Complementary and Alternative Medicine, v.2013, pp.1 - 5 | - |
dc.relation.isPartOf | Evidence-based Complementary and Alternative Medicine | - |
dc.citation.title | Evidence-based Complementary and Alternative Medicine | - |
dc.citation.volume | 2013 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordAuthor | INFLAMMATION | - |
dc.identifier.url | https://www.hindawi.com/journals/ecam/2013/824270/ | - |
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