Flurbiprofen-loaded nanoparticles prepared with polyvinylpyrrolidone using Shirasu porous glass membranes and a spray-drying technique: nano-sized formation and improved bioavailability
DC Field | Value | Language |
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dc.contributor.author | Oh, Dong Hoon | - |
dc.contributor.author | Din, Fakhar Ud | - |
dc.contributor.author | Kim, Dong Wuk | - |
dc.contributor.author | Kim, Jong Oh | - |
dc.contributor.author | Yong, Chul Soon | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.date.accessioned | 2021-06-23T05:44:17Z | - |
dc.date.available | 2021-06-23T05:44:17Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2013-02 | - |
dc.identifier.issn | 0265-2048 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/30967 | - |
dc.description.abstract | A unique flurbiprofen-loaded nanoemulsion was listed earlier using a Shirasu porous glass (SPG) membrane emulsification technique, which gave constant emulsion droplets with a thin size distribution. In this study, a flurbiprofen-loaded nanoemulsion was developed further into a solid form using polyvinylpyrrolidone (PVP) as a carrier by a spray-drying technique. The flurbiprofen-loaded nanoparticles with a weight ratio of flurbiprofen/PVP/surfactant mixture of 1/8/2 were connected with about 130 000-fold enhanced drug solubility and had a mean size of about 70 nm. In these nanoparticles, flurbiprofen was found in an altered amorphous state. Additionally, the nanoparticles gave significantly shorter T-max, and greater AUC and C-max compared to the commercially available product. Specially, the AUC of the drug from the nanoparticles was about 10-fold greater compared to the commercially available product. Therefore, these flurbiprofen-loaded nanoparticles can be convenient for distributing a poorly water-soluble flurbiprofen with improved bioavailability using uniform nano-sized particles. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | INFORMA HEALTHCARE | - |
dc.title | Flurbiprofen-loaded nanoparticles prepared with polyvinylpyrrolidone using Shirasu porous glass membranes and a spray-drying technique: nano-sized formation and improved bioavailability | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Dong Wuk | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.3109/02652048.2013.774447 | - |
dc.identifier.scopusid | 2-s2.0-84885359079 | - |
dc.identifier.wosid | 000325357300007 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROENCAPSULATION, v.30, no.7, pp.674 - 680 | - |
dc.relation.isPartOf | JOURNAL OF MICROENCAPSULATION | - |
dc.citation.title | JOURNAL OF MICROENCAPSULATION | - |
dc.citation.volume | 30 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 674 | - |
dc.citation.endPage | 680 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | SOLID-DISPERSION METHOD | - |
dc.subject.keywordPlus | ENHANCED BIOAVAILABILITY | - |
dc.subject.keywordPlus | GELATIN MICROCAPSULE | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordAuthor | Shirasu porous glass membrane | - |
dc.subject.keywordAuthor | spray drying | - |
dc.subject.keywordAuthor | nanoparticle | - |
dc.subject.keywordAuthor | flurbiprofen | - |
dc.subject.keywordAuthor | polyvinylpyrrolidone | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.3109/02652048.2013.774447 | - |
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