High Payload Dual Therapeutic-Imaging Nanocarriers for Triggered Tumor Delivery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jin-Ki | - |
dc.contributor.author | Yuan, Hong | - |
dc.contributor.author | Nie, Jingxin | - |
dc.contributor.author | Yang, Yu-Tsai | - |
dc.contributor.author | Leggas, Markos | - |
dc.contributor.author | Potter, Philip M. | - |
dc.contributor.author | Rinehart, John | - |
dc.contributor.author | Jay, Michael | - |
dc.contributor.author | Lu, Xiuling | - |
dc.date.accessioned | 2021-06-23T06:27:15Z | - |
dc.date.available | 2021-06-23T06:27:15Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/31836 | - |
dc.description.abstract | The in vitro and in vivo characterization of an optimized formulation of nanoparticles (NPs) loaded with a high content of dexamethasone palmitate (DEX-P), a chemotherapeutic adjuvant that decreases interstitial fluid pressure in tumors, and 111In, a signaling agent, is described. These NPs are uniform in size and composition. Single photon emission computed tomography imaging demonstrates significant tumor uptake of 111In-labeled DEX-P NPs in tumor-bearing mice. As with many nanoparticle-based drug delivery systems, significant liver accumulation is observed. Assessment of liver histology and blood tests show no apparent hepatic or renal toxicity of the DEX-P NPs. Conversion of DEX-P to DEX occurs when DEX-P NPs are incubated with mouse plasma, human tumor homogenate and ascites from tumor bearing mice, but not with human plasma. This conversion is slower in plasma from Es1e(-/-)/SCID mice, a potential alternative animal model that better mimics humans; however, plasma from these mice are not completely devoid of esterase activity. The difference between blood and tumor esterase activity in humans facilitates the delivery of DEX-P NPs to tumors and the release of dexamethasone by an esterase trigger. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | High Payload Dual Therapeutic-Imaging Nanocarriers for Triggered Tumor Delivery | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Ki | - |
dc.identifier.doi | 10.1002/smll.201200437 | - |
dc.identifier.scopusid | 2-s2.0-84866367246 | - |
dc.identifier.wosid | 000308874900015 | - |
dc.identifier.bibliographicCitation | SMALL, v.8, no.18, pp.2895 - 2903 | - |
dc.relation.isPartOf | SMALL | - |
dc.citation.title | SMALL | - |
dc.citation.volume | 8 | - |
dc.citation.number | 18 | - |
dc.citation.startPage | 2895 | - |
dc.citation.endPage | 2903 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | GLUCOCORTICOID-RECEPTOR | - |
dc.subject.keywordPlus | ANTIINFLAMMATORY AGENTS | - |
dc.subject.keywordPlus | CHEMOTHERAPY ADJUVANTS | - |
dc.subject.keywordPlus | CANCER-CHEMOTHERAPY | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | DEXAMETHASONE | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | GEMCITABINE | - |
dc.subject.keywordAuthor | nanoparticles | - |
dc.subject.keywordAuthor | dexamethasone | - |
dc.subject.keywordAuthor | ester prodrug | - |
dc.subject.keywordAuthor | triggered release | - |
dc.subject.keywordAuthor | SPECT | - |
dc.subject.keywordAuthor | CT imaging | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/smll.201200437 | - |
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