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A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Chae, Pil Seok | - |
| dc.contributor.author | Rasmussen, Soren G. F. | - |
| dc.contributor.author | Rana, Rohini R. | - |
| dc.contributor.author | Gotfryd, Kamil | - |
| dc.contributor.author | Kruse, Andrew C. | - |
| dc.contributor.author | Manglik, Aashish | - |
| dc.contributor.author | Cho, Kyung Ho | - |
| dc.contributor.author | Nurva, Shailika | - |
| dc.contributor.author | Gether, Ulrik | - |
| dc.contributor.author | Guan, Lan | - |
| dc.contributor.author | Loland, Claus J. | - |
| dc.contributor.author | Byrne, Bernadette | - |
| dc.contributor.author | Kobilka, Brian K. | - |
| dc.contributor.author | Gellman, Samuel H. | - |
| dc.date.accessioned | 2021-06-23T06:55:58Z | - |
| dc.date.available | 2021-06-23T06:55:58Z | - |
| dc.date.created | 2021-01-21 | - |
| dc.date.issued | 2012-07 | - |
| dc.identifier.issn | 0947-6539 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/32271 | - |
| dc.description.abstract | Non-traditional amphiphiles: Conferring aqueous solubility on membrane proteins generally requires the use of a detergent or other amphiphilic agent. A new class of amphiphiles was synthesized, based on steroidal lipophilic groups, and evaluated with several membrane proteins. The results show that the new amphiphile, "glyco-diosgenin" (GDN; see figure), confers enhanced stability to a variety of membrane proteins in solution relative to popular conventional detergents, such as dodecylmaltoside (DDM). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | - |
| dc.language | 영어 | - |
| dc.language.iso | en | - |
| dc.publisher | John Wiley & Sons Ltd. | - |
| dc.title | A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Chae, Pil Seok | - |
| dc.identifier.doi | 10.1002/chem.201200069 | - |
| dc.identifier.scopusid | 2-s2.0-84864136962 | - |
| dc.identifier.wosid | 000306670200005 | - |
| dc.identifier.bibliographicCitation | Chemistry - A European Journal, v.18, no.31, pp.9485 - 9490 | - |
| dc.relation.isPartOf | Chemistry - A European Journal | - |
| dc.citation.title | Chemistry - A European Journal | - |
| dc.citation.volume | 18 | - |
| dc.citation.number | 31 | - |
| dc.citation.startPage | 9485 | - |
| dc.citation.endPage | 9490 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
| dc.subject.keywordPlus | MUSCARINIC ACETYLCHOLINE-RECEPTOR | - |
| dc.subject.keywordPlus | FACIAL AMPHIPHILES | - |
| dc.subject.keywordPlus | AQUEOUS-SOLUTIONS | - |
| dc.subject.keywordPlus | HEMIFLUORINATED SURFACTANTS | - |
| dc.subject.keywordPlus | BETA(2) ADRENOCEPTOR | - |
| dc.subject.keywordPlus | STRUCTURAL INSIGHTS | - |
| dc.subject.keywordPlus | DETERGENT | - |
| dc.subject.keywordPlus | CHOLESTEROL | - |
| dc.subject.keywordPlus | AMPHIPOLS | - |
| dc.subject.keywordPlus | COMPLEX | - |
| dc.subject.keywordAuthor | amphiphiles | - |
| dc.subject.keywordAuthor | membrane proteins | - |
| dc.subject.keywordAuthor | molecular design | - |
| dc.subject.keywordAuthor | solubilization | - |
| dc.subject.keywordAuthor | stabilization | - |
| dc.identifier.url | https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.201200069 | - |
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Related Researcher
- Chae, Pil Seok
- ERICA 공학대학 (DEPARTMENT OF BIONANO ENGINEERING)