Biomimetic Scaffolds for Tissue Engineering
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Taek Gyoung | - |
dc.contributor.author | Shin, Heungsoo | - |
dc.contributor.author | Lim, Dong Woo | - |
dc.date.accessioned | 2021-06-23T07:17:14Z | - |
dc.date.available | 2021-06-23T07:17:14Z | - |
dc.date.issued | 2012-06 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.issn | 1616-3028 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/32610 | - |
dc.description.abstract | Biomimetic scaffolds mimic important features of the extracellular matrix (ECM) architecture and can be finely controlled at the nano- or microscale for tissue engineering. Rational design of biomimetic scaffolds is based on consideration of the ECM as a natural scaffold; the ECM provides cells with a variety of physical, chemical, and biological cues that affect cell growth and function. There are a number of approaches available to create 3D biomimetic scaffolds with control over their physical and mechanical properties, cell adhesion, and the temporal and spatial release of growth factors. Here, an overview of some biological features of the natural ECM is presented and a variety of original engineering methods that are currently used to produce synthetic polymer-based scaffolds in pre-fabricated form before implantation, to modify their surfaces with biochemical ligands, to incorporate growth factors, and to control their nano- and microscale geometry to create biomimetic scaffolds are discussed. Finally, in contrast to pre-fabricated scaffolds composed of synthetic polymers, injectable biomimetic scaffolds based on either genetically engineered- or chemically synthesized-peptides of which sequences are derived from the natural ECM are discussed. The presence of defined peptide sequences can trigger in situ hydrogelation via molecular self-assembly and chemical crosslinking. A basic understanding of the entire spectrum of biomimetic scaffolds provides insight into how they can potentially be used in diverse tissue engineering, regenerative medicine, and drug delivery applications. | - |
dc.format.extent | 23 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.title | Biomimetic Scaffolds for Tissue Engineering | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1002/adfm.201103083 | - |
dc.identifier.scopusid | 2-s2.0-84862027776 | - |
dc.identifier.wosid | 000304860500001 | - |
dc.identifier.bibliographicCitation | Advanced Functional Materials, v.22, no.12, pp 2446 - 2468 | - |
dc.citation.title | Advanced Functional Materials | - |
dc.citation.volume | 22 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2446 | - |
dc.citation.endPage | 2468 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | ELASTIN-LIKE POLYPEPTIDE | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | GROWTH-FACTOR DELIVERY | - |
dc.subject.keywordPlus | ARTIFICIAL PROTEIN HYDROGELS | - |
dc.subject.keywordPlus | BIODEGRADABLE MACROPOROUS SCAFFOLDS | - |
dc.subject.keywordPlus | EXTRACELLULAR-MATRIX PROTEINS | - |
dc.subject.keywordPlus | ASSEMBLING PEPTIDE HYDROGELS | - |
dc.subject.keywordPlus | BONE MORPHOGENETIC PROTEINS | - |
dc.subject.keywordPlus | ARTICULAR-CARTILAGE REPAIR | - |
dc.subject.keywordPlus | ELECTROSPUN NANOFIBERS | - |
dc.subject.keywordAuthor | biomimetic scaffolds | - |
dc.subject.keywordAuthor | biofunctionalization | - |
dc.subject.keywordAuthor | injectable biomaterials | - |
dc.subject.keywordAuthor | peptide hydrogels | - |
dc.subject.keywordAuthor | tissue engineering | - |
dc.subject.keywordAuthor | regenerative medicine | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201103083 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
55 Hanyangdeahak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, Korea+82-31-400-4269 sweetbrain@hanyang.ac.kr
COPYRIGHT © 2021 HANYANG UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.