Biofunctionalized AlGaN/GaN high electron mobility transistor for DNA hybridization detection
- Authors
- Thapa, Resham; Alur, Siddharth; Kim, Kyusang; Tong, Fei; Sharma, Yogesh; Kim, Moonil; Ahyi, Claude; Dai, Jing; Hong, Jong Wook; Bozack, Michael; Williams, John; Son, Ahjeong; Dabiran, Amir; Park, Minseo
- Issue Date
- Jun-2012
- Publisher
- AMER INST PHYSICS
- Citation
- APPLIED PHYSICS LETTERS, v.100, no.23, pp.1 - 5
- Indexed
- SCIE
SCOPUS
- Journal Title
- APPLIED PHYSICS LETTERS
- Volume
- 100
- Number
- 23
- Start Page
- 1
- End Page
- 5
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/32625
- DOI
- 10.1063/1.4727895
- ISSN
- 0003-6951
- Abstract
- Label-free electrical detection of deoxyribonucleic acid (DNA) hybridization was demonstrated using an AlGaN/GaN high electron mobility transistor (HEMT) based transducer with a biofunctionalized gate. The HEMT DNA sensor employed the immobilization of amine-modified single strand DNA on the self-assembled monolayers of 11-mercaptoundecanoic acid. The sensor exhibited a substantial current drop upon introduction of complimentary DNA to the gate well, which is a clear indication of the hybridization. The application of 3 base-pair mismatched target DNA showed little change in output current characteristics of the transistor. Therefore, it can be concluded that our DNA sensor is highly specific to DNA sequences. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4727895]
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Collections - COLLEGE OF ENGINEERING SCIENCES > DEPARTMENT OF BIONANO ENGINEERING > 1. Journal Articles
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