Fabrication of drug-loaded polymer microparticles with arbitrary geometries using a piezoelectric inkjet printing system
DC Field | Value | Language |
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dc.contributor.author | Lee, Byung Kook | - |
dc.contributor.author | Yun, Yeon Hee | - |
dc.contributor.author | Choi, Ji Suk | - |
dc.contributor.author | Choi, Young Chan | - |
dc.contributor.author | Kim, Jae Dong | - |
dc.contributor.author | Cho, Yong Woo | - |
dc.date.accessioned | 2021-06-23T07:39:50Z | - |
dc.date.available | 2021-06-23T07:39:50Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/33004 | - |
dc.description.abstract | Carrier geometry is a key parameter of drug delivery systems and has significant impact on the drug release rate and interaction with cells and tissues. Here we present a piezoelectric inkjet printing system as a simple and convenient approach for fabrication of drug-loaded polymer microparticles with well-defined and controlled shapes. The physical properties of paclitaxel (PTX)-loaded poly(lactic-co-glycolic acid) (PLGA) inks, such as volatility, viscosity and surface tension, were optimized for piezoelectric inkjet printing, and PTX-loaded PLGA microparticles were fabricated with various geometries, such as circles, grids, honeycombs, and rings. The resulting microparticles with 10% (w/w) PTX exhibited a fairly homogeneous shape and size. The microparticle fabrication by piezoelectric inkjet printing was precise, reproducible, and highly favorable for mass production. The microparticles exhibited a biphasic release profile with an initial burst due to diffusion and a subsequent, slow second phase due to degradation of PLGA. The release rate was dependent on the geometry, mainly the surface area, with a descending rate order of honeycomb > grid, ring > circle. The PTX-loaded microparticles showed a comparable activity in inhibiting the growth of HeLa cells. Our results demonstrate that a piezoelectric inkjet printing system would provide a new approach for large-scale manufacturing of drug carriers with a desired geometry. (C) 2012 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Fabrication of drug-loaded polymer microparticles with arbitrary geometries using a piezoelectric inkjet printing system | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Yong Woo | - |
dc.identifier.doi | 10.1016/j.ijpharm.2012.02.011 | - |
dc.identifier.scopusid | 2-s2.0-84862831272 | - |
dc.identifier.wosid | 000302364500021 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.427, no.2, pp.305 - 310 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.citation.title | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.citation.volume | 427 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 305 | - |
dc.citation.endPage | 310 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | MICROSPHERES | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordPlus | DEVICES | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | SHAPE | - |
dc.subject.keywordPlus | FLOW | - |
dc.subject.keywordPlus | LITHOGRAPHY | - |
dc.subject.keywordPlus | MICROSCALE | - |
dc.subject.keywordAuthor | Inkjet printing | - |
dc.subject.keywordAuthor | Microparticles | - |
dc.subject.keywordAuthor | Geometry | - |
dc.subject.keywordAuthor | Drug release | - |
dc.subject.keywordAuthor | In vitro cytotoxicity | - |
dc.identifier.url | https://linkinghub.elsevier.com/retrieve/pii/S0378517312001445 | - |
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