Transcriptome analysis shows ambiguous phenotypes of murine primitive endoderm-related stem cell lines
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhong, Yixiang | - |
dc.contributor.author | Binas, Bert | - |
dc.date.accessioned | 2021-06-22T10:21:22Z | - |
dc.date.available | 2021-06-22T10:21:22Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2019-04 | - |
dc.identifier.issn | 1356-9597 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/3384 | - |
dc.description.abstract | Primitive endoderm (PrE)-related cell lines (XEN, pXEN and nEnd cells) show key features of the PrE. By transcriptome analysis, we show: (a) Compared to embryonic stem cells, PrE-related cell lines are less in vivo like, although early nEnd cells are most similar to the PrE. (b) These cell lines show post-PrE features of parietal (XEN and pXEN cells) or visceral (nEnd cells) endoderm, likely driven by Tgf-beta and Wnt/Activin signaling, respectively. (c) pXEN and nEnd cell lines additionally show pre-PrE features. Hence, neither pXEN nor nEnd cell cultures represent a distinct in vivo entity. Rather, their properties are compatible with mixed and hybrid phenotypes. Our findings indicate that pre-PrE, PrE and early post-PrE phenotypes result from different niches, which need to be better understood to derive cell lines that distinctly represent the early stages of the extraembryonic endoderm. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Transcriptome analysis shows ambiguous phenotypes of murine primitive endoderm-related stem cell lines | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Binas, Bert | - |
dc.identifier.doi | 10.1111/gtc.12678 | - |
dc.identifier.scopusid | 2-s2.0-85063266631 | - |
dc.identifier.wosid | 000467079600006 | - |
dc.identifier.bibliographicCitation | GENES TO CELLS, v.24, no.4, pp.324 - 331 | - |
dc.relation.isPartOf | GENES TO CELLS | - |
dc.citation.title | GENES TO CELLS | - |
dc.citation.volume | 24 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 324 | - |
dc.citation.endPage | 331 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordAuthor | extraembryonic endoderm | - |
dc.subject.keywordAuthor | mice | - |
dc.subject.keywordAuthor | nEnd | - |
dc.subject.keywordAuthor | primitive endoderm (PrE) | - |
dc.subject.keywordAuthor | pXEN | - |
dc.subject.keywordAuthor | XEN | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/gtc.12678 | - |
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