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Protective effect of ginseng sapogenins against 2,2 '-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damage
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kang, Ki Sung | - |
| dc.contributor.author | Kim, Hyun Young | - |
| dc.contributor.author | Yoo, Hye Hyun | - |
| dc.contributor.author | Piao, Xiang Lan | - |
| dc.contributor.author | Ham, Jungyeob | - |
| dc.contributor.author | Yang, Hyun Ok | - |
| dc.contributor.author | Park, Jeong Hill | - |
| dc.date.accessioned | 2021-06-23T08:06:53Z | - |
| dc.date.available | 2021-06-23T08:06:53Z | - |
| dc.date.issued | 2012-01 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.issn | 1464-3405 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/33895 | - |
| dc.description.abstract | The effect of ginseng sapogenins, aglycone parts of ginsenosides, against oxidative damage by radical generator, 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH), in renal epithelial LLC-PK1 cells was investigated to identify the structural characteristics of sapogenins to have renoprotective effects. Of the tested sapogenins, Delta(20(21))-protopanaxatriol showed the strongest protective effect against the AAPH-induced LLC-PK1 cell damage. Based on the structure and stronger activity of Delta(20(21))-protopanaxatriol than the other sapogenins, the hydroxyl group in C-6 and double bond in C-20(21) position were important for renoprotective effect of sapogenin against oxidative stress. (C) 2011 Elsevier Ltd. All rights reserved. | - |
| dc.format.extent | 4 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | Pergamon Press Ltd. | - |
| dc.title | Protective effect of ginseng sapogenins against 2,2 '-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damage | - |
| dc.type | Article | - |
| dc.publisher.location | 영국 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2011.10.063 | - |
| dc.identifier.scopusid | 2-s2.0-84655161551 | - |
| dc.identifier.wosid | 000298636700125 | - |
| dc.identifier.bibliographicCitation | Bioorganic and Medicinal Chemistry Letters, v.22, no.1, pp 634 - 637 | - |
| dc.citation.title | Bioorganic and Medicinal Chemistry Letters | - |
| dc.citation.volume | 22 | - |
| dc.citation.number | 1 | - |
| dc.citation.startPage | 634 | - |
| dc.citation.endPage | 637 | - |
| dc.type.docType | Article | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | sci | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.subject.keywordPlus | RADICAL-SCAVENGING ACTIVITY | - |
| dc.subject.keywordPlus | HEAT-PROCESSED GINSENG | - |
| dc.subject.keywordPlus | DIABETIC-NEPHROPATHY | - |
| dc.subject.keywordPlus | RENAL DAMAGE | - |
| dc.subject.keywordPlus | GINSENOSIDES | - |
| dc.subject.keywordPlus | OXYGEN | - |
| dc.subject.keywordPlus | ANTIOXIDANT | - |
| dc.subject.keywordPlus | REDUCTION | - |
| dc.subject.keywordPlus | RATS | - |
| dc.subject.keywordPlus | RB-1 | - |
| dc.subject.keywordAuthor | Panax ginseng | - |
| dc.subject.keywordAuthor | Renoprotective activity | - |
| dc.subject.keywordAuthor | Ginsenoside | - |
| dc.subject.keywordAuthor | Sapogenin | - |
| dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0960894X11014612?via%3Dihub | - |
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Related Researcher
- Yoo, Hye Hyun
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)