The Polyoma Virus Large T Binding Protein p150 Is a Transcriptional Repressor of c-MYC
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sung, C.K. | - |
dc.contributor.author | Yim, H. | - |
dc.contributor.author | Gu, H. | - |
dc.contributor.author | Li, D. | - |
dc.contributor.author | Andrews, E. | - |
dc.contributor.author | Duraisamy, S. | - |
dc.contributor.author | Li, C. | - |
dc.contributor.author | Drapkin, R. | - |
dc.contributor.author | Benjamin, T. | - |
dc.date.accessioned | 2021-06-23T09:44:40Z | - |
dc.date.available | 2021-06-23T09:44:40Z | - |
dc.date.created | 2021-01-22 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/36226 | - |
dc.description.abstract | p150, product of the SALL2 gene, is a binding partner of the polyoma virus large T antigen and a putative tumor suppressor. p150 binds to the nuclease hypersensitive element of the c-MYC promoter and represses c-MYC transcription. Overexpression of p150 in human ovarian surface epithelial cells leads to decreased expression, and downregulation to increased expression, of c-MYC. c-MYC is repressed upon restoration of p150 to ovarian carcinoma cells. Induction of apoptosis by etoposide results in recruitment of p150 to the c-MYC promoter and to repression of c-MYC. Analysis of data in The Cancer Genome Atlas shows negative correlations between SALL2 and c-MYC expression in four common solid tumor types. © 2012 Sung et al. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.title | The Polyoma Virus Large T Binding Protein p150 Is a Transcriptional Repressor of c-MYC | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yim, H. | - |
dc.identifier.doi | 10.1371/journal.pone.0046486 | - |
dc.identifier.scopusid | 2-s2.0-84867009072 | - |
dc.identifier.wosid | 000309973900170 | - |
dc.identifier.bibliographicCitation | PLoS ONE, v.7, no.9, pp.1 - 7 | - |
dc.relation.isPartOf | PLoS ONE | - |
dc.citation.title | PLoS ONE | - |
dc.citation.volume | 7 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | binding protein | - |
dc.subject.keywordPlus | etoposide | - |
dc.subject.keywordPlus | Myc protein | - |
dc.subject.keywordPlus | protein p 150 | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | virus large T antigen | - |
dc.subject.keywordPlus | apoptosis | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | cancer cell | - |
dc.subject.keywordPlus | cancer classification | - |
dc.subject.keywordPlus | cancer genetics | - |
dc.subject.keywordPlus | cancer inhibition | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | down regulation | - |
dc.subject.keywordPlus | epithelium cell | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | gene | - |
dc.subject.keywordPlus | gene repression | - |
dc.subject.keywordPlus | genetic correlation | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | human cell | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | ovary | - |
dc.subject.keywordPlus | ovary cancer | - |
dc.subject.keywordPlus | promoter region | - |
dc.subject.keywordPlus | protein analysis | - |
dc.subject.keywordPlus | protein binding | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | SALL2 gene | - |
dc.subject.keywordPlus | solid tumor | - |
dc.subject.keywordPlus | transcription regulation | - |
dc.subject.keywordPlus | Antineoplastic Agents, Phytogenic | - |
dc.subject.keywordPlus | Base Sequence | - |
dc.subject.keywordPlus | Cell Line, Tumor | - |
dc.subject.keywordPlus | Etoposide | - |
dc.subject.keywordPlus | Gene Expression Regulation, Neoplastic | - |
dc.subject.keywordPlus | Genes, Tumor Suppressor | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Molecular Sequence Data | - |
dc.subject.keywordPlus | Neoplasms | - |
dc.subject.keywordPlus | Promoter Regions, Genetic | - |
dc.subject.keywordPlus | Protein Binding | - |
dc.subject.keywordPlus | Proto-Oncogene Proteins c-myc | - |
dc.subject.keywordPlus | Transcription Factors | - |
dc.subject.keywordPlus | Transcription, Genetic | - |
dc.subject.keywordPlus | Polyomavirus | - |
dc.subject.keywordAuthor | unclassified drug | - |
dc.subject.keywordAuthor | transcription regulation | - |
dc.subject.keywordAuthor | Antineoplastic Agents, Phytogenic | - |
dc.subject.keywordAuthor | protein p 150 | - |
dc.subject.keywordAuthor | Proto-Oncogene Proteins c-myc | - |
dc.subject.keywordAuthor | Humans | - |
dc.subject.keywordAuthor | epithelium cell | - |
dc.subject.keywordAuthor | Gene Expression Regulation, Neoplastic | - |
dc.subject.keywordAuthor | solid tumor | - |
dc.subject.keywordAuthor | Molecular Sequence Data | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | Myc protein | - |
dc.subject.keywordAuthor | ca | - |
dc.identifier.url | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046486 | - |
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