The Role of the Lignan Constituents in the Effect of Schisandra chinensis Fruit Extract on Penile Erection
DC Field | Value | Language |
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dc.contributor.author | Kim, Hye Kyung | - |
dc.contributor.author | Bak, Yun Ok | - |
dc.contributor.author | Choi, Bo Ram | - |
dc.contributor.author | Zhao, Chen | - |
dc.contributor.author | Lee, Hee Ju | - |
dc.contributor.author | Kim, Chul Young | - |
dc.contributor.author | Lee, Sung Won | - |
dc.contributor.author | Jeon, Ju Hong | - |
dc.contributor.author | Park, Jong Kwan | - |
dc.date.accessioned | 2021-06-23T10:04:47Z | - |
dc.date.available | 2021-06-23T10:04:47Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2011-12 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/36384 | - |
dc.description.abstract | The effect of the ethanol extract and active components of the fruit of Schisandra chinensis was evaluated on rabbit penile corpus cavernosum (PCC). PCC, pre-contracted with 10(-5) M phenylephrine (Phe), was treated with extracts of S. chinensis at five different compositions of ethanol and water (95%, 70%, 50%, 30% and ethanol/water [v/v]) and three fractions (0.1, 0.5, 1 and 2 mg/mL). The effect of the extracts and active lignans (schisandrol A and schisandrol B) from S. chinensis on sildenafil citrate pre-incubated PCC was also evaluated. The PCC relaxation induced by the 95% ethanol extraction and the n-hexane fraction was concentration-dependent and the ethanol extract enhanced sildenafil citrate-induced PCC relaxation. The active components of S. chinensis (schisandrol A and schisandrol B) significantly enhanced sildenafil citrate-induced relaxation >2-fold; schisandrol A had the highest relaxant effect on sildenafil citrate pre-incubated PCC. The lignans, schisandrol A and schisandrol B, isolated from the fruits of S. chinensis enhanced sildenafil citrate-induced relaxation and may have synergistic action in patients who do not completely respond to sildenafil. Copyright (C) 2011 John Wiley & Sons, Ltd. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | The Role of the Lignan Constituents in the Effect of Schisandra chinensis Fruit Extract on Penile Erection | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chul Young | - |
dc.identifier.doi | 10.1002/ptr.3486 | - |
dc.identifier.scopusid | 2-s2.0-82155175121 | - |
dc.identifier.wosid | 000298277900007 | - |
dc.identifier.bibliographicCitation | PHYTOTHERAPY RESEARCH, v.25, no.12, pp.1776 - 1782 | - |
dc.relation.isPartOf | PHYTOTHERAPY RESEARCH | - |
dc.citation.title | PHYTOTHERAPY RESEARCH | - |
dc.citation.volume | 25 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1776 | - |
dc.citation.endPage | 1782 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | SCHIZANDRA-CHINENSIS | - |
dc.subject.keywordPlus | DIBENZOCYCLOOCTADIENE LIGNANS | - |
dc.subject.keywordPlus | PHARMACOKINETIC COMPARISONS | - |
dc.subject.keywordPlus | CORPUS CAVERNOSUM | - |
dc.subject.keywordPlus | BAILL | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | RELAXATION | - |
dc.subject.keywordPlus | CGMP | - |
dc.subject.keywordAuthor | Schisandra chinensis | - |
dc.subject.keywordAuthor | penile corpus cavernosum | - |
dc.subject.keywordAuthor | sildenafil citrate | - |
dc.subject.keywordAuthor | schisandrol A | - |
dc.subject.keywordAuthor | schisandrol B | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/ptr.3486 | - |
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