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Synthesis and Biological Evaluation of 1-Heteroarylmethyl 1,4-Diazepanes Derivatives as Potential T-type Calcium Channel Blockers
Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ullapu, Punna Reddy | - |
| dc.contributor.author | Ku, Su Jin | - |
| dc.contributor.author | Choi, Yeon Hee | - |
| dc.contributor.author | Park, Jiyeon | - |
| dc.contributor.author | Han, So-Yeop | - |
| dc.contributor.author | Baek, Du Jong | - |
| dc.contributor.author | Lee, Jaekyun | - |
| dc.contributor.author | Pae, Ae Nim | - |
| dc.contributor.author | Min, Sun-Joon | - |
| dc.contributor.author | Cho, Yong Seo | - |
| dc.date.accessioned | 2021-06-23T10:38:51Z | - |
| dc.date.available | 2021-06-23T10:38:51Z | - |
| dc.date.created | 2021-01-21 | - |
| dc.date.issued | 2011-08 | - |
| dc.identifier.issn | 0253-2964 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/37242 | - |
| dc.description.abstract | The synthesis and biological evaluation of 1-heteroarylmethyl 1,4-diazepane derivatives as potential T-type calcium channel blockers is described. In this study, we have identified the compound 211 exhibiting the most potent T-type calcium channel blocking activity with IC(50) value of 0.20 mu M, which is superior to that of mibefradil. | - |
| dc.language | 영어 | - |
| dc.language.iso | en | - |
| dc.publisher | 대한화학회 | - |
| dc.title | Synthesis and Biological Evaluation of 1-Heteroarylmethyl 1,4-Diazepanes Derivatives as Potential T-type Calcium Channel Blockers | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Min, Sun-Joon | - |
| dc.identifier.doi | 10.5012/bkcs.2011.32.8.3063 | - |
| dc.identifier.scopusid | 2-s2.0-84866768417 | - |
| dc.identifier.wosid | 000297383700048 | - |
| dc.identifier.bibliographicCitation | Bulletin of the Korean Chemical Society, v.32, no.8, pp.3063 - 3073 | - |
| dc.relation.isPartOf | Bulletin of the Korean Chemical Society | - |
| dc.citation.title | Bulletin of the Korean Chemical Society | - |
| dc.citation.volume | 32 | - |
| dc.citation.number | 8 | - |
| dc.citation.startPage | 3063 | - |
| dc.citation.endPage | 3073 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.identifier.kciid | ART001576729 | - |
| dc.description.journalClass | 1 | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.description.journalRegisteredClass | kci | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
| dc.subject.keywordPlus | CA2+ CHANNELS | - |
| dc.subject.keywordPlus | ANTAGONISTS | - |
| dc.subject.keywordPlus | INHIBITION | - |
| dc.subject.keywordPlus | ACID | - |
| dc.subject.keywordAuthor | T-type calcium channel blockers | - |
| dc.subject.keywordAuthor | 1,4-Diazepanes | - |
| dc.subject.keywordAuthor | Heteroaromatic compounds | - |
| dc.subject.keywordAuthor | FDSS6000 assay | - |
| dc.subject.keywordAuthor | Patch-clamp assay | - |
| dc.identifier.url | http://koreascience.or.kr/article/JAKO201128762648678.page | - |
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Related Researcher
- Min, Sun Joon
- ERICA 공학대학 (ERICA 에너지바이오학과)